業績

  • 渡部徹郎
  • 横山三紀
  • 粂井康宏
  • 井上Katarzyna Anna
  • 吉松康裕
  • 2017

    1. Akatsu Y, Yoshimatsu Y, Tomizawa T, Takahashi K, Katsura A, Miyazono K,
      Watabe T
      . Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. Cancer Sci. 2017 Jan;108(1):151-155. doi: 10.1111/cas.13103. [Pubmed]
    2. Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA,
      Watabe T, Sato Y. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling.
      Cancer Sci. 2017 Mar;108(3):419-426. doi: 10.1111/cas.13157.[Pubmed]
    3. Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, Hara-Yokoyama M. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
      Exp Cell Res. 2017 Jan 1;350(1):103-114. doi: 10.1016/j.yexcr.2016.11.011. Epub 2016 Nov 16.[Pubmed]

    2016

    1. Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K. Stem Cell Reports. 2016 Jan 12;6(1):64-73. doi: 10.1016/j.stemcr.2015.12.004.[Pubmed]
    2. Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y, Miyazono K. Genes Cells. 2016 Jan;21(1):99-116. doi: 10.1111/gtc.12323. Epub 2015 Dec 10.[Pubmed]
    3. Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M,Katarzyna A Podyma-lnoue, Anupama R Rajapakshe, Watabe T, Shirouzu M, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016 Jan. O; 479(3); 489-495[Pubmed]
    4. Ogata F, Fujiu K, Matsumoto S, Nakayama Y, Shibata M, Oike Y, Koshima I, Watabe T, , Nagai R, Manabe I. Excess lymphangiogenesis co-operatively induced by macrophages and CD4+ T cells drives the pathogenesis of lymphedema. Journal of Investigative Dermatology.. 2016 Mar.; 136(3); 706-714[Pubmed]
    5. Muguruma K, Yakushiji F, Kawamata R, Akiyama D, Arima R, Shirasaka T, Kikkawa Y, Taguchi A, Takayama K, Fukuhara T, Watabe T, Ito Y, Hayashi Y. Novel Hybrid Compound of a Plinabulin Prodrug with an lgG Binding Peptide for Generating a Tumor Selective Noncovalent-Type Antibody-Drug Conjugate. Bioconjug. Chem .. 2016 Jul.; 27(7); 1606-1613[Pubmed]

    2014

    1. Itoh F, Watabe T, Miyazono K. (2014) Roles of TGF-β family signals in the fate determination of pluripotent stem cells. Semin Cell Dev Biol. 32:98-106. (Epub 2014 Jun 6.) [Pubmed]
    2. Miyazaki H*, Yoshimatsu Y*, Akatsu Y, Mishima K, Fukayama M, Watabe T, (2014) Miyazono K. Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis. Cancer Sci. 105(9):1116-23. (Epub 2014 Sep 11.) (*equally contributed)
      [Pubmed]

    2013

    1. Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI,Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T. (2013) Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc Natl Acad Sci USA. 110:18940-18945.
    2. Yamazaki T, Suehiro J, Miyazaki H, Minami T, Kodama T, Miyazono K, Watabe T. (2013) The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII. Biochemical Journal. 452:345-357.
    3. Suzuki HI, Mihira H, Watabe T, Sugimoto K, Miyazono K. (2013) Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis. Nucleic Acids Research. 41:e62.

    2012

    1. Takaesu NT, Stinchfield MJ, Shimizu K, Arase M, Quijano JC, Watabe T, Miyazono K, Newfeld SJ. (2012) Drosophila CORL is required for Smad2-mediated activation of Ecdysone Receptor expression in the mushroom body. Development. 139:3392-3401.
    2. Kawata M, Koinuma D, Ogami T, Umezawa K, Iwata C, Watabe T, Miyazono K. (2012) TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. Journal of Biochemistry. 151:205-216.
    3. Mihira H, Suzuki HI, Akatsu Y, Yoshimatsu Y, Igarashi T, Miyazono K, Watabe T. (2012) TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. Journal of Biochemistry. 143:199-206.
    4. Watabe T. (2012) Roles of transcriptional network during the formation of lymphatic vessels. J Biochem. 152:213-220. (Review)
    5. Watabe T. (2012) Roles of Dppa2 in the regulation of the present status and future of pluripotent stem cells. J Biochem. 152:1-3. (Commentary)

    2011

    1. Azuma K, Urano T, Watabe T, Ouchi Y, Inoue S. (2011) PROX1 suppresses vitamin K-induced transcriptional activity of Steroid and Xenobiotic Receptor. Genes to Cells. 16:1063-1070.
    2. Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, Harada K, Morikawa M, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T. (2011) Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. Journal of Cell Science. 124:2753-2762.
    3. Takahashi S, Watanabe T, Okada M, Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, Kato S. (2011) Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A. 108: 4938-4943.
    4. Yoshimatsu Y, Watabe T. (2011) Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fibrosis. Int J Inflam. 2011:724080. (Review)
    5. Watabe T. (2011) Roles of old players in the suppression of a new player: networks for the transcriptional control of angiogenesis. J Biochem. 149: 117-119. (Commentary)

    〜2010

    1. Suzuki Y, Ohga N, Morishita Y, Hida K, Miyazono K, Watabe T. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. Journal of Cell Science. 123:1684-1692.
    2. Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K. (2009) Identification of Prox1 targets during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. Journal of Cell Science. 122: 3923-3930.
    3. Yamamizu K, Kawasaki K, Katayama S, Watabe T, Yamashita JK. (2009) Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and neuropilin-1. Blood. 114: 3707-3716.
    4. Sase H, Watabe T, Kawasaki K, Miyazono K, Miyazawa K. (2009) VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells. Journal of Cell Science. 122:3303-3311.
    5. Saito RA, Watabe T, Horiguchi K, Kohyama T, Saitoh M, Nagase T, Miyazono K. (2009) TTF-1 inhibits TGF-β mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells. Cancer Research. 69:2783-2791.
    6. Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T. (2009) COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes to Cells. 14:425-434.
    7. Watabe T, Miyazono K. (2009) Roles of TGF-β family signaling in stem cell renewal and differentiation. Cell Research. 19:103-115. (Review)
    8. Katsu M, Koyama H, Maekawa H, Kurihara H, Uchida H, Hamada H. (2009) Ex vivo gene delivery of ephrin-B2 induces development of functional collateral vessels in a rabbit model of hind limb ischemia. Journal of Vascular Surgery. 49:192-198.
    9. Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, * Watabe T (*: corresponding author), Miyazono K. (2008) Snail is required for TGF-β induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. Journal of Cell Science. 121:3317-3324.
    10. Nonaka H, Watabe T, Saito S, Miyazono K, Miyajima A. (2008) Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGF-β /activin signaling. Biochemical and Biophysical Research Communications. 375:256-260.
    11. Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K. (2008) Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. Journal of Cell Biology. 181:131-141.
    12. Oka M, Iwata C, Suzuki H, Kiyono K, Morishita Y, Watabe T, Komuro A, Kano MR, Miyazono K. (2008) Inhibition of endogenous TGF-β signaling enhances lymphangiogenesis. Blood. 111:4571-4579.
    13. Suzuki Y, Montagne K,Nishihara A, * Watabe T (*: corresponding author), Miyazono K. (2008) BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and Angiopoietin-1/Tie2 signals. Journal of Biochemistry. 143:199-206.
    14. Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P. (2008) Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. Prostate. 68:139-151.
    15. Watabe T, Miyazono K. (2008) TGF- family signaling in stem cell renewal and differentiation. The TGF- Family. (Cold Spring Harbor Laboratory Press) 585-612. (Review)
    16. Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K. (2007) Prox1 induces lymphatic endothelial differentiation via integrin β9 and other signaling cascades. Molecular Biology of the Cell. 18:1421-1429.
    17. Ogawa K, Saito A, Matsui H, Suzuki H, Ohtsuka S, Shimosato D, Morishita Y, Watabe T, Niwa H, Miyazono K. (2007) Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. Journal of Cell Science. 120:55-65.
    18. Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S, Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, and Horie S (2005) Effect of Smad7 Expression on Metastasis of Mouse Mammary Carcinoma JygMC(A) Cells. Journal of National Cancer Institute. 97:1734-1746.
    19. Watabe T, Mishima K, Yamashita J, and Miyazono K. (2006) TGF-β signaling in embryonic stem cell-derived endothelial cells (book chapter). Embryonic Stem Cells-II: Methods and Protocols (Humana Press) 330:341-351. (Review)
    20. Kano MR, Morishita Y, Iwata C, Iwasaka S, Watabe T, Ouchi Y, Miyazono K, Miyazawa K. (2005) VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRβ signaling. Journal of Cell Science. 118:3759-3768.
    21. Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JK, Obi S, Ohura N, Matsushita A, Kamiya A, Ando J (2005) Fluid Shear Stress Induces Differentiation of Flk-1-Positive Embryonic Stem Cells into Vascular Endothelial Cells In Vitro. American Journal of Physiology - Heart and Circulatory Physiology. 288:915-924.
    22. Suzuki H, Watabe T, Miyazawa K, Kato M, and Miyazono K. (2005) Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Blood. 105:2372-2379.
    23. Miyazaki H, Watabe T, Kitamura T, and Miyazono K. (2004) BMP Signals Inhibit Proliferation and In Vivo Tumor Growth of Androgen Insensitive Prostate Carcinoma Cells. Oncogene. 23:9326-9335.
    24. Mochizuki T, Miyazaki H, Hara T, Furuya T, Imamura T, Watabe T, Miyazono K. (2004) Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-β superfamily signaling. Journal of Biological Chemistry. 279: 31568-31574.
    25. Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T. (2004) USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochemical and Biophysical Research Communications. 316:490-500.
    26. Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K. (2004) Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Molecular Biology of the Cell. 15:963-972.
    27. Okumura E, Fukuhara T, Yoshida H, Hanada S, Kozutsumi R, Mori M, Tachibana K, Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa SI, and Miyazono K. (2003) TGF- receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. Journal of Cell Biology. 163:1303-1311.
    28. Takebayashi-Suzuki K, Funami J, Tokumori D, Saito A, Watabe T, Miyazono K, Kanda A, and Suzuki A. (2003) Interplay between the tumor suppressor p53 and TGF-β signaling shapes embryonic body axes in Xenopus. Development. 130:3929-3939.
    29. Murakami G, Watabe T, Takaoka T, Miyazono K and Imamura T. (2003) Multi-step Inhibition of BMP Signaling by Smurf1. Molecular Biology of the Cell. 14:2809-2817.
    30. Nishihara A, Watabe T, Imamura T, Miyazono K. (2002) Functional Heterogeneity of Bone Morphogenetic Protein Receptor-II Mutants Found in Patients with Primary Pulmonary Hypertension. Molecular Biology of the Cell. 13:3055-3063.
    31. Watabe T, Lin M, Reiter RE, Witte ON. (2001) Growth, Regeneration and Tumorigenesis of the Prostate Activates the PSCA Promoter. Proceedings of National Academy of Sciences U.S.A. 99:401-406.
    32. Mochizuki T, Karavanov AA, Curtiss PE, Ault KT, Sugimoto N, Watabe T, Shiokawa K, Jamrich M, Cho KW, Dawid IB, Taira M. (2000) Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. Developmental Biology. 224:470-485.
    33. Reiter RE, Sato I, Thomas G, Qian J, Gu Z, Watabe T, Loda M, Jenkins RB. (2000) Coamplification of prostate stem cell antigen (PSCA) and MYC in locally advanced prostate cancer. Genes, Chromosomes and Cancer. 27:95-103.
    34. Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. (1998) Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proceedings of National Academy of Sciences U.S.A. 95:1735-1740.
    35. *Candia AF, *Watabe T (*: contributed equally), Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW. (1997) Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development. 124:4467-4480.
    36. Watabe T., Candia, A., Cho, KW. (1997). Activin signaling pathways and their role in Xenopus mesoderm formation. (book chapter).“Inhibin, activin and follistatin”. Serano Symposium. Springer-Verlag, NY. (Review)
    37. Watabe T, Kim S, Candia A, Rothbacher U, Hashimoto C, Inoue K, Cho KW. (1995) Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes & Development. 9:3038-3050.
    38. Hawley SH, Wunnenberg-Stapleton K, Hashimoto C, Laurent MN, Watabe T, Blumberg BW, Cho KW. (1995) Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes & Development. 9:2923-2935.
    39. Rothbacher U, Laurent MN, Blitz IL, Watabe T, Marsh JL, Cho KW. (1995) Functional conservation of the Wnt signaling pathway revealed by ectopic expression of Drosophila dishevelled in Xenopus. Developmental Biology. 170:717-721
  • 2017

    1. Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, Hara-Yokoyama M. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
      Exp Cell Res. 2017 Jan 1;350(1):103-114. doi: 10.1016/j.yexcr.2016.11.011. Epub 2016 Nov 16.[Pubmed]

    2016

    1. Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Katarzyna A Podyma-lnoue, Anupama R Rajapakshe,Watabe T, Shirouzu M, Hara-Yokoyama M. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016 Jan. O; 479(3); 489-495[Pubmed]
    2. Katarzyna A Podyma-lnoue. Moriwaki T, Anupama R Rajapakshe, Terasawa K, Hara-Yokoyama M. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016 Dec.; 13(6); 443-452[Pubmed]

    2015

    1. Terasawa K, Rajapakshe AR, Podyma-Inoue KA, Mishima-Tsumagari C, Yanagishita M, Hara-Yokoyama M. (2015) Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL. J Immunol Methods. 420:1-10. (Epub 2015 Mar 13.)[Pubmed]

    2014

    1. Rajapakshe AR, Podyma-Inoue KA, Terasawa K, Hasegawa K, Namba T, Kumei Y, Yanagishita M, Hara-Yokoyama M. (2015) Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. Exp Cell Res. 331(1):211-22. (Epub 2014 Sep 22.)[Pubmed]

    2013

    1. Hara-Yokoyama M, Terasawa K, Ichinose S, Watanabe A, Podyma-Inoue KA, Akiyoshi K, Igarashi Y, Yanagishita M. (2013) Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. Bioorg Med Chem Lett. 23(7):2220-4. (Epub 2013 Jan 30.)
    2. Hara-Yokoyama M. (2013) Glycosylation Regulates CD38 Assembly on the Cell Surface. Trends in Glycoscience and Glycotechnology 25:215-225

    2012

    1. Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M. (2012) Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities. Structure. 20(9):1585-95. (Epub 2012 Aug 2.)
    2. Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Ikutani M, Takaki S, Sakamoto K, Hara-Yokoyama M, Shirouzu M, Takatsu K, Yokoyama S. (2012) Structural basis of interleukin-5 dimer recognition by its α receptor. Protein Sci. 21(6):850-64.( Epub 2012 Apr 23.)
    3. Podyma-Inoue KA, Hara-Yokoyama M, Shinomura T, Kimura T, Yanagishita M. (2012) Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. PLoS One. 7(3):e32351. (Epub 2012 Mar 1.)

    2011

    1. Ebe N, Hara-Yokoyama M, Iwasaki K, Iseki S, Okuhara S, Podyma-Inoue KA, Terasawa K, Watanabe A, Akizuki T, Watanabe H, Yanagishita M, Izumi Y. (2011)Pocket epithelium in the pathological setting for HMGB1 release. J Dent. Res. 90(2):235-40. (Epub 2010 Dec 13.)

    〜2010

    1. Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato C, Kitajima K, Ogawa H. (2010) Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. J. Biol. Chem. 285, 17301-17309.
    2. Yanagishita M, Podyma-Inoue KA, Yokoyama M. (2009) Extraction and separation of proteoglycans. Glycoconjugate Journal 26, 953-9
    3. Hara-Yokoyama M, Kimura T, Kaku H, Wakiyama M, Kaitsu Y, Inoue M, Kusano S, Shirouzu M, Yokoyama S, Katada T, Hirabayashi Y, Takatsu K, Yanagishita M. (2008) Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation. Int Immunopharmacol. 8(1):59-70. (Epub 2007 Nov 1.)
    4. Katsumata O, Fujita-Yoshigaki J, Hara-Yokoyama M, Yanagishita M, Furuyama S, Sugiya H. (2007) Syntaxin6 separates from GM1a-rich membrane microdomain during granule maturation. Biochem Biophys Res Commun. 357(4):1071-7. (Epub 2007 Apr 18.)
    5. Hara-Yokoyama M. (2006) Gangliosides potentially inhibit extracellular nucleotide metabolism. Curr Med Chem. 13(19):2233-9. Review.
    6. Ueno-Noto K, Hara-Yokoyama M, Takano K. (2006) Recognition of tandem sialic acid residues by CD38: a theoretical study. J Comput Chem. 15;27(1):53-60.
    7. Katsumata O, Kimura T, Nagatsuka Y, Hirabayashi Y, Sugiya H, Furuyama S, Yanagishita M, Hara-Yokoyama M. (2004) Charge-based separation of detergent-resistant membranes of mouse splenic B cells. Biochem Biophys Res Commun. 319(3):826-31.
    8. Hara-Yokoyama M, Ito H, Ueno-Noto K, Takano K, Ishida H, Kiso M. (2003) Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38. Bioorg Med Chem Lett. 13(20):3441-5.
    9. Nagatsuka Y, Hara-Yokoyama M, Kasama T, Takekoshi M, Maeda F, Ihara S, Fujiwara S, Ohshima E, Ishii K, Kobayashi T, Shimizu K, Hirabayashi Y. (2003) Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells. Proc Natl Acad Sci U S A. 100(13):7454-9. (Epub 2003 Jun 11.)
    10. Dohke Y, Fujita-Yoshigaki J, Sugiya H, Furuyama S, Hara-Yokoyama M. (2002) Involvement of phospholipase D in the cAMP-regulated exocytosis of rat parotid acinar cells. Biochem Biophys Res Commun. 299(4):663-8.
    11. Katsumata O, Hara-Yokoyama M, Sautès-Fridman C, Nagatsuka Y, Katada T, Hirabayashi Y, Shimizu K, Fujita-Yoshigaki J, Sugiya H, Furuyama S. (2001) Association of FcgammaRII with low-density detergent-resistant membranes is important for cross-linking-dependent initiation of the tyrosine phosphorylation pathway and superoxide generation. J Immunol. 167(10):5814-23.
    12. Sugiya H, Mitsui Y, Michikawa H, Fujita-Yoshigaki J, Hara-Yokoyama M, Hashimoto S, Furuyama S. (2001) Ca(2+)-regulated nitric oxide generation in rabbit parotid acinar cells. Cell Calcium. 30(2):107-16.
    13. Hara-Yokoyama M, Nagatsuka Y, Katsumata O, Irie F, Kontani K, Hoshino S, Katada T, Ono Y, Fujita-Yoshigaki J, Sugiya H, Furuyama S, Hirabayashi Y. (2001) Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38. Biochemistry. 40(4):888-95.
    14. Kukimoto M, Nureki O, Shirouzu M, Katada T, Hirabayashi Y, Sugiya H, Furuyama S, Yokoyama S, Hara-Yokoyama M. (2000) Crystallization and preliminary X-ray diffraction analysis of the extracellular domain of the cell surface antigen CD38 complexed with ganglioside. J Biochem. 127(2):181-4.
    15. Fujita-Yoshigaki J, Dohke Y, Hara-Yokoyama M, Furuyama S, Sugiya H. (1999) Presence of a complex containing vesicle-associated membrane protein 2 in rat parotid acinar cells and its disassembly upon activation of cAMP-dependent protein kinase. J Biol Chem. 274(33):23642-6.
    16. Michikawa H, Mitsui Y, Fujita-Yoshigaki J, Hara-Yokoyama M, Furuyama S, Sugiya H. (1998) cGMP production is coupled to Ca(2+)-dependent nitric oxide generation in rabbit parotid acinar cells. Cell Calcium. 23(6):405-12.
    17. Sugiya H, Michikawa H, Mitsui Y, Fujita-Yoshigaki J, Hara-Yokoyama M, Furuyama S. (1998) Ca2+-nitric oxide-cGMP signaling in rabbit parotid acinar cells. Eur J Morphol. 36 Suppl:194-7. Review.
    18. Dohke Y, Hara-Yokoyama M, Fujita-Yoshigaki J, Furuyama S, Sugiya H. (1998) ADP-ribosylation factors in rat parotid acinar cells. Eur J Morphol. 36 Suppl:186-9. Review.
    19. Fujita-Yoshigaki J, Dohke Y, Hara-Yokoyama M, Furuyama S, Sugiya H. (1998) Snare proteins essential for cyclic AMP-regulated exocytosis in salivary glands. Eur J Morphol. 36 Suppl:46-9. Review.
    20. Dohke Y, Hara-Yokoyama M, Fujita-Yoshigaki J, Kahn RA, Kanaho Y, Hashimoto S, Sugiya H, Furuyama S. (1998) Translocation of Arf1 to the secretory granules in rat parotid acinar cells. Arch Biochem Biophys. 357(1):147-54.
    21. Fujita-Yoshigaki J, Dohke Y, Hara-Yokoyama M, Kamata Y, Kozaki S, Furuyama S, Sugiya H. (1996) Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis in rat parotid acinar cells. The inhibition of cAMP-dependent amylase release by botulinum neurotoxin B. J Biol Chem. 271(22):13130-4.
    22. Hara-Yokoyama M, Kukimoto I, Nishina H, Kontani K, Hirabayashi Y, Irie F, Sugiya H, Furuyama S, Katada T. (1996) Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides. J Biol Chem. 271(22):12951-5.
    23. Hara-Yokoyama M, Hirabayashi Y, Irie F, Syuto B, Moriishi K, Sugiya H, Furuyama S. (1995) Identification of gangliosides as inhibitors of ADP-ribosyltransferases of pertussis toxin and exoenzyme C3 from Clostridium botulinum. J Biol Chem. 270(14):8115-21.
    24. Hara-Yokoyama M, Sugiya H, Furuyama S, Wang JH, Yokoyama N. (1994) Dephosphorylation of ribosomal protein S6 phosphorylated via the cAMP-mediated signaling pathway in rat parotid gland: effect of okadaic acid and Zn2+. Biochem Mol Biol Int. 34(6):1177-87.
    25. Hara-Yokoyama M, Sugiya H, Furuyama S. (1994) Possible involvement of adenylylation in the modification of a 26 kDa protein in rat parotid acinar cells. Int J Biochem. 26(9):1103-9.
    26. Yokoyama N, Hara-Yokoyama M, Kobayashi T, Tamura S, Furuyama S, Sugiya H. (1994) Involvement of type 2C phosphatase in the dephosphorylation of 26 kDa phosphoprotein in rat parotid acinar cells. Biochem Biophys Res Commun. 200(1):497-503.
    27. Sugiya H, Hara-Yokoyama M, Furuyama S. (1992) Isoproterenol-stimulated labelling of particulate proteins by using [adenylate-32P]NAD+ independent on a cAMP-dependent protein kinase in parotid acinar cells. FEBS Lett. 300(2):171-4.
    28. Nureki O, Suzuki K, Hara-Yokoyama M, Kohno T, Matsuzawa H, Ohta T, Shimizu T, Morikawa K, Miyazawa T, Yokoyama S. (1992) Glutamyl-tRNA synthetase from Thermus thermophilus HB8. Molecular cloning of the gltX gene and crystallization of the overproduced protein. Eur J Biochem. 204(2):465-72.
    29. Haruki M, Matsumoto R, Hara-Yokoyama M, Miyazawa T, Yokoyama S. (1990) Conformational changes of aminoacyl-tRNA and uncharged tRNA upon complex formation with polypeptide chain elongation factor Tu. FEBS Lett. 263(2):361-4.
    30. Hara-Yokoyama M, Furuyama S. (1989) An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain. Biochem Biophys Res Commun. 160(1):67-71.
    31. Hara-Yokoyama M, Furuyama S. (1988) Endogenous inhibitor of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin is present in rat liver. FEBS Lett. 234(1):27-30.
    32. Hara-Yokoyama M, Yokoyama S, Miyazawa T. (1986) Conformation change of tRNAGlu in the complex with glutamyl-tRNA synthetase is required for the specific binding of L-glutamate. Biochemistry. 25(22):7031-6.
    33. Yokoyama S, Haruki M, Hara-Yokoyama M, Miyazawa T. (1986) Circular dichroism analyses of tRNA X protein interactions. Nucleic Acids Symp Ser. 1986;(17):199-201.
    34. Horie N, Hara-Yokoyama M, Yokoyama S, Watanabe K, Kuchino Y, Nishimura S, Miyazawa T. (1985) Two tRNAIle1 species from an extreme thermophile, Thermus thermophilus HB8: effect of 2-thiolation of ribothymidine on the thermostability of tRNA. Biochemistry. 24(21):5711-5.
    35. Hara-Yokoyama M, Yokoyama S, Miyazawa T. (1984) Purification and characterization of glutamyl-tRNA synthetase from an extreme thermophile, Thermus thermophilus HB8. J Biochem. 96(5):1599-607.
  • 2016

    1. Kumei Y, Shimokawa R, Kimoto , Kawauchi Y, Shimokawa H, Makita K, Ohya K, Toda K. Gravity stress elevates the nociceptive threshold level with immunohistochemical changes in the rat brain. Acta Astronaut. 49(3-1 O); 381-390
      [Pubmed]

    2015

    1. Pletser V, Kumei Y. (2015) Parabolic Flights. in “Generation and applications of extra-terrestrial environments on Earth” (eds. Beysens, DA, van Loon, JJWA) pp.61-73, River Publishers (Delft, The Netherlands)
    2. de Campos PS, Hasegawa K, Kumei Y, Zeredo JL. (2015) Cineradiographic analysis of respiratory movements in a mouse model for early Parkinson's disease. Respir Physiol Neurobiol. 218:40-5. (Epub 2015 Jul 11.)
      [Pubmed]
    3. Rajapakshe AR, Podyma-Inoue KA, Terasawa K, Hasegawa K, Namba T, Kumei Y, Yanagishita M, Hara-Yokoyama M. (2015) Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. Exp Cell Res. 331(1):211-22. (Epub 2014 Sep 22.)
      [Pubmed]

    2014

    1. Zeredo ZL, Toda K, Kumei Y. (2014) Neuronal Activity in the Subthalamic Cerebrovasodilator Area under Partial-Gravity Conditions in Rats. Life (Basel). 4(1):107-16.[Pubmed]
    2. Hasegawa K, de Campos PS, Zeredo JL, Kumei Y. (2014) Cineradiographic analysis of mouse postural response to alteration of gravity and jerk (gravity deceleration rate). Life (Basel). 4(2):174-88.
      [Pubmed]

    2012

    1. Zeredo JL, Toda K, Matsuura M, Kumei Y. (2012) Behavioral responses to partial-gravity conditions in rats. Neurosci Lett. 529(2):108-11. (Epub 2012 Oct 2.)
      [Pubmed]

    2011

    1. Kumei Y, Akiyama H, Onizuka T, Kobayashi C. (2011) Variation of telomeric DNA content in gingiva and dental pulp. Arch Oral Biol. 56(12):1641-5. (Epub 2011 Sep 8.)
      [Pubmed]

    〜2010

    1. Zeredo JL, Kumei Y, Shibazaki T, Yoshida N, Toda K. (2009) Measuring biting behavior induced by acute stress in the rat. Behav Res Methods. 41(3):761-4.
      [Pubmed]
    2. Kumei Y, Shimokawa H, Ohya K, Katano H, Akiyama H, Hirano M, Morita S. (2007) Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight. Ann NY Acad Sci. 1095:292-9.
      [Pubmed]
    3. Kumei Y, Morita S, Katano H, Akiyama H, Hirano M, Oyha K, Shimokawa H. (2006) Microgravity signal ensnarls cell adhesion, cytoskeleton, and matrix proteins of rat osteoblasts: osteopontin, CD44, osteonectin, and alpha-tubulin. Ann NY Acad Sci. 1090:311-7.
      [Pubmed]
    4. Zeredo JL, Sasaki KM, Kumei Y, Toda K. (2006) Hindlimb withdrawal reflexes evoked by Er:YAG laser and scalpel incisions in rats. Photomed Laser Surg. 24(5):595-600.
      [Pubmed]
    5. Morita S, Jinno T, Nakamura H, Kumei Y, Shinomiya K, Yamamoto H. (2005) Bone mineral density and walking ability of elderly patients with hip fracture: a strategy for prevention of hip fracture. Injury. 36(9):1075-9.
      [Pubmed]
    6. Morita S, Nakamura H, Kumei Y, Shimokawa H, Ohya K, Shinomiya K. (2004) Hypergravity stimulates osteoblast phenotype expression: a therapeutic hint for disuse bone atrophy. Ann NY Acad Sci. 1030:158-61.
      [Pubmed]
    7. Kumei Y, Morita S, Nakamura H, Katano H, Ohya K, Shimokawa H, Sams CF, Whitson PA. (2004) Osteoblast responsiveness to 1alpha, 25-dihydroxyvitamin D3 during spaceflight. Ann NY Acad Sci. 1030:121-4.
      [Pubmed]
    8. Kumei Y, Morita S, Nakamura H, Akiyama H, Katano H, Shimokawa H, Ohya K. (2004) Platelet-activating factor receptor signals in rat osteoblasts during spaceflight. Ann NY Acad Sci. 1030:116-20.
      [Pubmed]
    9. Kumei Y, Morita S, Nakamura H, Akiyama H, Hirano M, Shimokawa H, Ohya K. (2003) Coinduction of GTP cyclohydrolase I and inducible NO synthase in rat osteoblasts during space flight: apoptotic and self-protective response? Ann NY Acad Sci. 1010:481-5.
      [Pubmed]
    10. Kumei Y, Morita S, Shimokawa H, Ohya K, Akiyama H, Hirano M, Sams CF, Whitson PA. (2003) Inhibition of HSP70 and a collagen-specific molecular chaperone (HSP47) expression in rat osteoblasts by microgravity. Ann NY Acad Sci. 1010:476-80.
      [Pubmed]
    11. Nakamura H, Kumei Y, Morita S, Shimokawa H, Ohya K, Shinomiya K. (2003) Antagonism between apoptotic (Bax/Bcl-2) and anti-apoptotic (IAP) signals in human osteoblastic cells under vector-averaged gravity condition. Ann NY Acad Sci. 1010:143-7.
      [Pubmed]
    12. Nakamura H, Kumei Y, Morita S, Shimokawa H, Ohya K, Shinomiya K. (2003) Suppression of osteoblastic phenotypes and modulation of pro- and anti-apoptotic features in normal human osteoblastic cells under a vector-averaged gravity condition. J Med Dent Sci. 50(2):167-76.
      [Pubmed]
    13. Yuge L, Hide I, Kumagai T, Kumei Y, Takeda S, Kanno M, Sugiyama M, Kataoka K. (2003) Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat. In Vitro Cell Dev Biol Anim. 39(1-2):89-97.
      [Pubmed]
    14. Kumei Y, Morita S, Nakamura H, Shinomiya K, Ohya K, Shimokawa H. (2002) Does microgravity induce apoptotic signal in rat osteoblasts via cjun-n-terminal kinase? J Gravit Physiol. 9(1):263-4.
      [Pubmed]
    15. Kumei Y, Shimokawa R, Toda K, Kawauchi Y, Makita K, Terasawa M, Ohya K, Shimokawa H. (2002) Hypergravity modulates behavioral nociceptive responses in rats. Adv Space Res. 30(4):783-8.
      [Pubmed]
    16. Kumei Y, Nakamura H, Morita S, Akiyama H, Hirano M, Ohya K, Shinomiya K, Shimokawa H. (2002) Space flight and insulin-like growth factor-I signaling in rat osteoblasts. Ann NY Acad Sci. 973:75-8.
      [Pubmed]
    17. Kumei Y, Shimokawa R, Terasawa M, Shimokawa H, Kawauchi Y, Makita K, Ohya K, Toda K. (2001) Hypergravity and opioid-mediated pain suppression in rats. J Gravit Physiol. 8(1):111-2.
      [Pubmed]
    18. Kumei Y, Shimokawa R, Kimoto M, Kawauchi Y, Shimokawa H, Makita K, Ohya K, Toda K. (2001) Gravity stress elevates the nociceptive threshold level with immunohistochemical changes in the rat brain. Acta Astronaut. 49(3-10):381-90.
      [Pubmed]
    19. Kumei Y, Shimokawa R, Kawauchi Y, Terasawa M, Toda K, Shimokawa H. (2001) [Gravity stress modulates pain sensation of rat via hypothalamus]. Biol Sci Space. 15(3):288-9.
      [Pubmed]
    20. Sato A, Kumei Y, Sato K, Hongo T, Hamazaki T, Masuda I, Nakajima T, Ohmura T, Kaiho M, Sato T, Wake K. (2001) Studies on the effects of microgravity on the ultrastructure and function of cultured mammalian cells. Biol Sci Space. 15 Suppl:S61-3.
      [Pubmed]
    21. Kumei Y, Akiyama H, Hirano M, Nakamura H, Shinomiya K, Ohya K, Shimokawa H. (2001) [Microgravity modulates function of osteoblast]. Biol Sci Space. 15(3):190-1.
      [Pubmed]
    22. Kumei Y, Toda K, Kawauchi Y, Shimokawa R, Shimokawa H, Makita K. (2000) Nociceptive responses and immunohistochemical changes in the rat brain under gravity stress. J Gravit Physiol. 7(2):91-2.
      [Pubmed]
    23. Kumei Y, Akiyama H, Hirano M, Shimokawa H, Morita S, Mukai C, Nagaoka S. (1999) Space flight modulates signal transduction pathway of growth factor receptors in rat osteoblasts. Biol Sci Space. 13(3):142-3.
      [Pubmed]
    24. Akiyama H, Kanai S, Hirano M, Shimokawa H, Katano H, Mukai C, Nagaoka S, Morita S, Kumei Y. (1999) Expression of PDGF-beta receptor, EGF receptor, and receptor adaptor protein Shc in rat osteoblasts during spaceflight. Mol Cell Biochem. 202(1-2):63-71.
      [Pubmed]
    25. Kumei Y, Shimokawa H, Katano H, Akiyama H, Hirano M, Mukai C, Nagaoka S, Whitson PA, Sams CF. (1998) Spaceflight modulates insulin-like growth factor binding proteins and glucocorticoid receptor in osteoblasts. J Appl Physiol. 85(1):139-47.
      [Pubmed]
    26. Akiyama H, Kanai S, Hirano M, Kumei Y, Shimokawa H, Katano H, Hara E, Song S, Mukai C, Nagaoka S. (1996) An improved quantitative RT-PCR fluorescent method for analysis of gene transcripts in the STS-65 space shuttle experiment. J Biotechnol. 47(2-3):325-33.
      [Pubmed]
    27. Kumei Y, Shimokawa H, Katano H, Hara E, Akiyama H, Hirano M, Mukai C, Nagaoka S, Whitson PA, Sams CF. (1996) Microgravity induces prostaglandin E2 and interleukin-6 production in normal rat osteoblasts: role in bone demineralization. J Biotechnol. 47(2-3):313-24.
      [Pubmed]
    28. Kumei Y, Whitson PA. (1994) Hypergravity signal transduction and gene expression in cultured mammalian cells. J Gravit Physiol. 1(1):P88-9.
      [Pubmed]
    29. Sato A, Nakajima T, Kumei Y, Hongo T, Ozawa K. (1992) Gravitational effects on mammalian cells. Physiologist. 35(1 Suppl):S43-6.
      [Pubmed]
    30. Kumei Y, Whitson PA, Sato A, Cintrón NM. (1991) Hypergravity signal transduction in HeLa cells with concomitant phosphorylation of proteins immunoprecipitated with anti-microtubule-associated protein antibodies. Exp Cell Res. 192(2):492-6.
      [Pubmed]
    31. Kumei Y, Nakajima T, Sato A, Kamata N, Enomoto S. (1989) Reduction of G1 phase duration and enhancement of c-myc gene expression in HeLa cells at hypergravity. J Cell Sci. 93 (Pt 2):221-6.
      [Pubmed]
  • 2017

    1. Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA,
      Watabe T, Sato Y. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling.
      Cancer Sci. 2017 Mar;108(3):419-426. doi: 10.1111/cas.13157.[Pubmed]
    2. Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, Hara-Yokoyama M. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
      Exp Cell Res. 2017 Jan 1;350(1):103-114. doi: 10.1016/j.yexcr.2016.11.011. Epub 2016 Nov 16.[Pubmed]

    2016

    1. Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Podyma-Inoue KA, Anupama R Rajapakshe,Watabe T, Shirouzu M, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016 Jan. O; 479(3); 489-495[Pubmed]
    2. Podyma-Inoue KA. Moriwaki T, Anupama R Rajapakshe, Terasawa K, Hara-Yokoyama M. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016 Dec.; 13(6); 443-452[Pubmed]

    2015

    1. Watari I, Abbassy MA, Podyma-Inoue KA and Ono T (2015). Complication of Type 1 Diabetes in Craniofacial and Dental Hard Tissue, Major Topics in Type 1 Diabetes, Dr. Kenia Nunes (Ed.), ISBN: 978-953-51-2204-3, InTech, DOI: 10.5772/61885. Available from: http://www.intechopen.com/books/major-topics-in-type-1-diabetes/complication-of-type-1-diabetes-in-craniofacial-and-dental-hard-tissue (book chapter)
    2. Terasawa K, Rajapakshe AR, Podyma-Inoue KA, Mishima-Tsumagari C, Yanagishita M, Hara-Yokoyama M. Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL. (2015) Journal of Immunological Methods. 420:1-10[Pubmed]
    3. Rajapakshe AR*, Podyma-Inoue KA*, Terasawa K, Hasegawa K, Namba T, Yasuhiro Kumei Y, Yanagishita M, Hara-Yokoyama M. Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. (2015) Experimental Cell Research. 331:211-222. (*equally contributed)[Pubmed]

    2014

    1. Aoyama E, Watari I, Podyma-Inoue KA, Yanagishita M, Ono T. Expression of glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells. (2014) International Journal of Molecular Medicine. 34: 475-482.[Pubmed]
    2. Ippei W, Privatananupunt J, Jui-Chin H, Podyma-Inoue KA, Aoyama E and Ono T. (2014) The influence of gestational diabetes in craniofacial growth of newborn rat Journal of Society for Women's Health Science Research. 3: 57-62
    3. Privatananupunt J, Watari I, Podyma-Inoue KA, Kubono M, Ono T. Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands. (2014) Acta Histochemica. 116: 545-550.[Pubmed]

    2013

    1. Kasekarn K, Podyma-Inoue KA and Yanagishita M. Effect of lipopolysaccharide from Porphyromonas gingivalis on expression of heparanase in human gingival epithelial cell line, Ca9-22. (2013) Chulalongkorn University Dental Journal. 36: 143-152.
    2. Takehara S, Yanagishita M, Podyma-Inoue KA, Kawaguchi Y. Degradation of MUC7 and MUC5B in human saliva. (2013) PLoS ONE. 8: e69059.[Pubmed]
    3. Hara-Yokoyama M, Terasawa K, Ichinose S, Watanabe A, Podyma-Inoue KA, Akiyoshi K, Igarashi Y, Yanagishita M. Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. (2013) Bioorganic and Medicinal Chemistry Letters. 23: 2220-2224. [Pubmed]

    2012

    1. Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M. Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities. (2012) Structure. 20: 1585-1595.[Pubmed]
    2. Podyma-Inoue KA, Hara-Yokoyama M, Shinomura T, Kimura T, Yanagishita M. Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. (2012) PLoS ONE. 7: e32351.[Pubmed]

    2011

    1. Ebe N, Hara-Yokoyama M, Iwasaki K, Iseki S, Okuhara S, Podyma-Inoue KA, Terasawa K, Watanabe A, Akizuki T, Watanabe H, Yanagishita M, Izumi Y. Pocket epithelium in the pathological setting for HMGB1 release. (2011) Journal of Dental Research. 90: 235-240.[Pubmed]

    ~2010

    1. Takehara S, Yanagishita M, Podyma-Inoue KA, Ueno M, Shinada K, Kawaguchi Y. Relationship between oral malodor and glycosylated salivary proteins. (2010) Journal of Medical and Dental Sciences. 57: 25-33.[Pubmed]
    2. Yanagishita M, Podyma-Inoue KA, Yokoyama M. Extraction and separation of proteoglycans. (2009) Glycoconjugate Journal. 26: 953-959.[Pubmed]
    3. Yanagishita M, Podyma-Inoue KA. Golgi and Lysosomal Disease: Degradation of hyaluronan and its disorder (2008) Taniguchi N, Suzuki A, Ito A, Narimatsu H, Kawasaki T, Hase S (Eds.). Experimental Glycoscience: Glycobiology. P216-218. Springer. ISBN: 978-4-431-77921-6, DOI: 10.1007/978-4-431-77922-3, (book section).[Springer Link]
    4. Tsuchida S, Podyma-Inoue KA, Yokoyama M, Fukasawa K, Ishihara A, Yanagishita M, Yoshinari N. Use of proteomics in research on periodontal disease. (2007) Journal of the Japanese Society of Periodontology. 49: 257-263.
    5. Yanagishita M, Tsuchida S, Yokoyama M, Inoue KA. Effect of p-nitrophenyl-xyloside on the biosynthesis of proteoglycan in rat ovarian granulosa cells--analyses of glycosaminoglycan synthesis in the Golgi apparatus. (2006) Kokubyo Gakkai Zasshi 73: 20-25.[Pubmed]
    6. Dias RA, Shibata S, Hashimoto-Uoshima M, Podyma-Inoue KA, Ishikawa I, Yanagishita M. Syndecan-1 expression during the formation of junctional epithelium. (2005) Journal of Periodontology. 76: 696-704.[Pubmed]
    7. Ozaki S, Kaneko S, Podyma-Inoue KA, Yanagishita M, Soma K. Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress. (2005) Journal of Periodontal Research. 40:110-7.[Pubmed]
    8. Tsuchida S, Podyma-Inoue KA, Yanagishita M. Ultrafiltration-based assay for heparanase activity. (2004) Analytical Biochemistry. 331: 147-152.[Pubmed]
    9. Hashimoto-Uoshima M, Dias RA, Noguchi K, Podyma KA, Yanagishita M and Ishikawa I. Effects of cytokines on proteoglycan biosynthesis in human periodontal tissue cells (2004) The Japanese Journal of Conservative Dentistry. 47: 684-695.
    10. Kurokawa K, Katsube K, Podyma KA, Ikuta M, Iseki H, Nakajima M, Akashi T, Omura K, Takagi M, Yanagishita M. Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts. (2003) Cancer Science. 94: 277-285. [Pubmed]
    11. Podyma-Inoue KA, Yokote H, Sakaguchi K, Ikuta M, Yanagishita M. Characterization of heparanase from a rat parathyroid cell line. (2002) Journal of Biological Chemistry. 277: 32459-32465.[Pubmed]
    12. Ikuta M, Podyma KA, Maruyama K, Enomoto S, Yanagishita M. Expression of heparanase in oral cancer cell lines and oral cancer tissues. (2001) Oral Oncology. 37: 177-184.[Pubmed]
    13. Podyma KA, Yamagata S, Sakata K, Yamagata T. Difference of hyaluronidase produced by human tumor cell lines with hyaluronidase present in human serum as revealed by zymography. (1997) Biochemical and Biophysical Research Communications. 241: 446-452.[Pubmed]
  • 2017

    1. Akatsu Y, Yoshimatsu Y, Tomizawa T, Takahashi K, Katsura A, Miyazono K,
      Watabe T. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. Cancer Sci. 2017 Jan;108(1):151-155. doi: 10.1111/cas.13103. [Pubmed]
    2. Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA,
      Watabe T, Sato Y. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling.
      Cancer Sci. 2017 Mar;108(3):419-426. doi: 10.1111/cas.13157.[Pubmed]

    2014

    1. Miyazaki H*, Yoshimatsu Y*, Akatsu Y, Mishima K, Fukayama M, Watabe T, (2014) Miyazono K. Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis. Cancer Sci. 105(9):1116-23. (Epub 2014 Sep 11.) (*equally contributed)
      [Pubmed]

    2013

    1. Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI,Maruyama K,
      Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T. (2013) Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc Natl Acad Sci USA. 110:18940-18945.

    2012

    1. Mihira H, Suzuki HI, Akatsu Y, Yoshimatsu Y, Igarashi T, Miyazono K,Watabe T. (2012) TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. Journal of Biochemistry. 143:199-206.

    2011

    1. Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, Harada K, Morikawa M, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T. (2011) Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. Journal of Cell Science. 124:2753-2762.
    2. Yoshimatsu Y, Watabe T. (2011) Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fibrosis. Int J Inflam. 2011:724080. (Review)

    〜2010

    1. Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K. (2009) Identification of Prox1 targets during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. Journal of Cell Science. 122: 3923-3930.
    2. Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T. (2009) COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes to Cells. 14:425-434.
    3. Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, * Watabe T (*: corresponding author), Miyazono K. (2008) Snail is required for TGF-β induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. Journal of Cell Science. 121:3317-3324.
    4. Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K. (2007) Prox1 induces lymphatic endothelial differentiation via integrin β9 and other signaling cascades. Molecular Biology of the Cell. 18:1421-1429.
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