Publication

  • Tetsuro Watabe
  • Miki Yokoyama
  • Katarzyna Anna Inoue
  • Miho Kobayashi
  • Kazuki Takahashi

  • 2024

    1. Takahashi K, Kobayashi M, Katsumata H, Tokizaki S, Anzai T, Ikeda Y, Alcaide DM, Maeda K, Ishihara M, Tahara K, Kubota Y, Itoh F, Park J, Takahashi K, Matsunaga YT, Yoshimatsu Y, Podyma-Inoue KA, *Watabe T. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023 Dec 18. doi: 10.1111/cas.16045. Epub ahead of print. [Pubmed]
    2. Tokizaki S, Podyma-Inoue KA, Matsumoto T, Takahashi K, Kobayashi M, Ibi H, Uchida S, Iwabuchi S, Harada H, Hashimoto S, Miyazono K, *Watabe T. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023 Nov 16. doi: 10.1111/cas.16006. Epub ahead of print. [Pubmed]

    2023

    1. Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system. Watabe T, Takahashi K, Pietras K, Yoshimatsu Y. Semin Cancer Biol. 2023 Jul;92:130-138. doi: 10.1016/j.semcancer.2023.04.007. [Pubmed]

    2022

    1. Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis. Inubushi T, Fujiwara A, Hirose T, Aoyama G, Uchihashi T, Yoshida N, Shiraishi Y, Usami Y, Kurosaka H, Toyosawa S, Tanaka S, Watabe T, Kogo M, Yamashiro T. Dis Model Mech . 2022 Feb 1;15(2):dmm049093. doi: 10.1242/dmm.049093. Epub 2022 Feb 15. PMID: 34897389[Pubmed]
    2. The two-domain architecture of LAMP2A regulates its interaction with Hsc70. Ikami Y, Terasawa K, Sakamoto K, Ohtake K, Harada H, Watabe T, Yokoyama S, Hara-Yokoyama M. Exp Cell Res . 2022 Feb 1;411(1):112986. doi: 10.1016/j.yexcr.2021.112986. Epub 2021 Dec 21. PMID: 34942188[Pubmed]
    3. Emerging roles of inflammation-mediated endothelial-mesenchymal transition in health and disease. Yoshimatsu Y, Watabe T. Inflamm Regen . 2022 Feb 7;42(1):9. doi: 10.1186/s41232-021-00186-3. PMID: 35130955[Pubmed]
    4. Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF-β-expressing CD206+ cells compared with skin. Nakayama K, Nishijo T, Miyazawa M, Watabe T, Azuma M, Sakaguchi H. Immun Inflamm Dis . 2022 Apr;10(4):e605. doi: 10.1002/iid3.605. PMID: 35349751[Pubmed]
    5. Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition. Kobayashi M, Fujiwara K, Takahashi K, Yoshioka Y, Ochiya T, Podyma-Inoue KA, Watabe T. Inflamm Regen . 2022 Sep 4;42(1):38. doi: 10.1186/s41232-022-00225-7. PMID: 36057626[Pubmed]
    6. An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis. Takahashi K, Abe K, Kubota SI, Fukatsu N, Morishita Y, Yoshimatsu Y, Hirakawa S, Kubota Y, Watabe T, Ehata S, Ueda HR, Shimamura T, Miyazono K. Nat Commun . 2022 Sep 12;13(1):5239. doi: 10.1038/s41467-022-32848-2. PMID: 36097010[Pubmed]
    7. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via keratin-associated protein 2-3. Takahashi K, Podyma-Inoue KA, Saito M, Sakakitani S, Sugauchi S, Iida K, Iwabuchi S, Koinuma D, Kurioka K, Konishi T, Tanaka S, Kaida A, Miura M, Hashimoto S, Okada M, Uchihashi T, Miyazono K, Watabe T. Cell Reports , 2022, Sep 27;40: 111411. doi: 10.1016/cellrep.2022.111411.[Paper]
    8. TGF-β signaling in lymphatic vascular vessel formation and maintenance. Itoh F, Watabe T. Front Physiol. 2022 Dec 15;13:1081376. doi:[Pubmed]

    2021

    1. Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Sakakitani S, Podyma-Inoue KA, Takayama R, Takahashi K, Ishigami-Yuasa M, Kagechika H, Harada H, Watabe T. Cancer Sci . 2021 Jan;112(1):155-67. doi: 10.1111/cas.14670. Online ahead of print.PMID: 33007125[Pubmed]
    2. Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors. Kobayashi M, Wakabayashi I, Suzuki Y, Fujiwara K, Nakayama M, Watabe T, Sato Y. Angiogenesis . 2021 Feb;24(1):159-176. doi: 10.1007/s10456-020-09754-6. Epub 2020 Oct 14. PMID: 33052495[Pubmed]
    3. Angiogenic Effects of Secreted Factors from Periodontal Ligament Stem Cells. Iwasaki K, Akazawa K, Nagata M, Komaki M, Peng Y, Umeda M, Watabe T, Morita I. Dent J (Basel) . 2021 Jan 15;9(1):9. doi: 10.3390/dj9010009. PMID: 33467531[Pubmed]
    4. ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis. Fujimoto M, Kamiyama M, Fuse K, Ryuno H, Odawara T, Furukawa N, Yoshimatsu Y, Watabe T, Prchal-Murphy M, Sexl V, Tahara H, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H. Cancer Sci . 2021 Apr;112(4):1633-1643. doi: 10.1111/cas.14842. Epub 2021 Mar 6. PMID: 33565179[Pubmed]
    5. Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells. Terasawa K, Kato Y, Ikami Y, Sakamoto K, Ohtake K, Kusano S, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Guan JL, Kobayashi T, Iwata T, Watabe T, Yokoyama S, Hara-Yokoyama M. Autophagy . 2021 Dec;17(12):4286-4304. doi: 10.1080/15548627.2021.1911017. Epub 2021 Apr 14. PMID: 33849387[Pubmed]
    6. Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. Nishino K, Yoshimatsu Y, Muramatsu T, Sekimoto Y, Mitani K, Kobayashi E, Okamoto S, Ebana H, Okada Y, Kurihara M, Suzuki K, Inazawa J, Takahashi K, Watabe T, Seyama K. Sci Rep . 2021 Apr 16;11(1):8406. doi: 10.1038/s41598-021-88064-3. PMID: 33863980[Pubmed]
    7. Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor. Kodama S, Podyma-Inoue KΑ, Uchihashi T, Kurioka K, Takahashi H, Sugauchi A, Takahashi K, Inubushi T, Kogo M, Tanaka S, Watabe T. Oncol Rep . 2021 Sep;46(3):197. doi: 10.3892/or.2021.8148. Epub 2021 Jul 23. PMID: 34296292[Pubmed]
    8. Construction of transplantable artificial vascular tissue based on adipose tissue-derived mesenchymal stromal cells by a cell coating and cryopreservation technique. Asano Y, Okano D, Matsusaki M, Watabe T, Yoshimatsu Y, Akashi M, Shimoda H. Sci Rep . 2021 Sep 9;11(1):17989. doi: 10.1038/s41598-021-97547-2. PMID: 34504254[Pubmed]

    2020

    1. Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis.Yamamoto D, Kayamori K, Sakamoto K, Tsuchiya M, Ikeda T, Harada H, Yoda T, Watabe T , Hara-Yokoyama M .Cancer Sci . 2020 Feb;111(2):700-712. doi: 10.1111/cas.14249. Epub 2019 Dec 20.PMID:31769164 [Pubmed]
    2. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Kato Y,Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T , Hara-Yokoyama M . Bioorg Med Chem Lett . 2020 Feb 1;30(3):126891. doi: 10.1016/j.bmcl.2019.126891. Epub 2019 Dec 17.PMID:31874824 [Pubmed]
    3. Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Yang W, Podyma-Inoue KA , Yonemitsu I, Watari I, Ikeda Y, Guo X, Watabe T , Ono T. Clin Oral Investig .2020 Feb 7. doi: 10.1007/s00784-020-03225-4. Online ahead of print.PMID: 32034544 [Pubmed]
    4. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals. Yoshimatsu Y, Kimuro S, Pauty J, Takagaki K, Nomiyama S, Inagawa A, Maeda K,Podyma-Inoue KA ,Kajiya K, Matsunaga YT, Watabe T .PLoS One . 2020 May 1;15(5):e0232356. doi: 10.1371/journal.pone.0232356. eCollection 2020.PMID: 32357159 [Pubmed]
    5. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M , Maishi N, Podyma-Inoue KA , Hida K, Miyazono K, Watabe T . Cancer Sci . 2020 May 9. doi: 10.1111/cas.14455. Online ahead of print .PMID: 32385953 [Pubmed]
    6. Peptide-2 from mouse myostatin precursor protein alleviates muscle wasting in cancer-associated cachexia.Ojima C, Noguchi Y, Miyamoto T, Saito Y, Orihashi H, Yoshimatsu Y, Watabe T , Takayama K, Hayashi Y, Itoh F. Cancer Sci . 2020 Jun 10. doi: 10.1111/cas.14520. Online ahead of print.PMID: 32519375[Pubmed]
    7. Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. Takahashi K, Akatsu Y, Podyma-Inoue KA , Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T . J Biol Chem . 2020 Jul 6:jbc.RA120.012492. doi: 10.1074/jbc.RA120.012492. Online ahead of print.PMID: 32631954[Pubmed]

    2019

    1. Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma.Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T.Sci Rep. 2019 Feb 4;9(1):1281. doi: 10.1038/s41598-019-39018-3.[Pubmed]
    2. The Fate of Transplanted Periodontal Ligament Stem Cells in Surgically Created Periodontal Defects in Rats.Iwasaki K, Akazawa K, Nagata M, Komaki M, Honda I, Morioka C, Yokoyama N, Ayame H, Yamaki K, Tanaka Y, Kimura T, Kishida A, Watabe T , Morita I.Int J Mol Sci. 2019 Jan 7;20(1). pii: E192. doi: 10.3390/ijms20010192.[Pubmed]
    3. Changes in characteristics of periodontal ligament stem cells in spheroid culture.Iwasaki K, Nagata M, Akazawa K, Watabe T, Morita I.J Periodontal Res. 2018 Dec 30. doi: 10.1111/jre.12637. [Epub ahead of print][Pubmed]
    4. Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae.Ren E, Watari I, Jui-Chin H, Mizumachi-Kubono M, Podyma-Inoue KA, Narukawa M, Misaka T, Watabe T, Ono T.Acta Histochem. 2019 Feb;121(2):135-142. doi: 10.1016/j.acthis.2018.10.007. Epub 2018 Nov 23. [Pubmed]

    2018

    1. Takahashi K, Podyma-Inoue KA , Takao C, Yoshimatsu Y , Muramatsu T,Inazawa J, Watabe T. Regulatory role of transforming growth factor-βsignals in the migration and tumor formation of HOC313-LM cells, anoral squamous cell carcinoma.The Journal of theStomatological Society, 85: 52-61, 2018

    2017

    1. Fukuhara T, Kim J, Hokaiwado S, Nawa M, Okamoto H, Kogiso T, Watabe T, Hattori N. A novel immunotoxin reveals a new role for CD321 in endothelial cells. PLoS One. 2017 Oct 13;12(10):e0181502. doi: 10.1371/journal.pone.0181502.[Pubmed]
    2. Akatsu Y, Yoshimatsu Y, Tomizawa T, Takahashi K, Katsura A, Miyazono K,
      Watabe T      . Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. Cancer Sci. 2017 Jan;108(1):151-155. doi: 10.1111/cas.13103. [Pubmed]
    3. Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA,
      Watabe T, Sato Y. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling.
      Cancer Sci. 2017 Mar;108(3):419-426. doi: 10.1111/cas.13157.[Pubmed]
    4. Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, Hara-Yokoyama M. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
      Exp Cell Res. 2017 Jan 1;350(1):103-114. doi: 10.1016/j.yexcr.2016.11.011. Epub 2016 Nov 16.[Pubmed]

    2016

    1. Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K. Stem Cell Reports. 2016 Jan 12;6(1):64-73. doi: 10.1016/j.stemcr.2015.12.004.[Pubmed]
    2. Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y, Miyazono K. Genes Cells. 2016 Jan;21(1):99-116. doi: 10.1111/gtc.12323. Epub 2015 Dec 10.[Pubmed]
    3. Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M,Katarzyna A Podyma-lnoue, Anupama R Rajapakshe, Watabe T, Shirouzu M, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016 Jan. O; 479(3); 489-495[Pubmed]
    4. Ogata F, Fujiu K, Matsumoto S, Nakayama Y, Shibata M, Oike Y, Koshima I, Watabe T, , Nagai R, Manabe I. Excess lymphangiogenesis co-operatively induced by macrophages and CD4+ T cells drives the pathogenesis of lymphedema. Journal of Investigative Dermatology.. 2016 Mar.; 136(3); 706-714[Pubmed]
    5. Muguruma K, Yakushiji F, Kawamata R, Akiyama D, Arima R, Shirasaka T, Kikkawa Y, Taguchi A, Takayama K, Fukuhara T, Watabe T, Ito Y, Hayashi Y. Novel Hybrid Compound of a Plinabulin Prodrug with an lgG Binding Peptide for Generating a Tumor Selective Noncovalent-Type Antibody-Drug Conjugate. Bioconjug. Chem .. 2016 Jul.; 27(7); 1606-1613[Pubmed]

    2014

    1. Itoh F, Watabe T, Miyazono K. (2014) Roles of TGF-β family signals in the fate determination of pluripotent stem cells. Semin Cell Dev Biol. 32:98-106. (Epub 2014 Jun 6.) [Pubmed]
    2. Miyazaki H*, Yoshimatsu Y*, Akatsu Y, Mishima K, Fukayama M, Watabe T, (2014) Miyazono K. Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis. Cancer Sci. 105(9):1116-23. (Epub 2014 Sep 11.) (*equally contributed)
      [Pubmed]

    2013

    1. Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI,Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T. (2013) Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc Natl Acad Sci USA. 110:18940-18945.
    2. Yamazaki T, Suehiro J, Miyazaki H, Minami T, Kodama T, Miyazono K, Watabe T. (2013) The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII. Biochemical Journal. 452:345-357.
    3. Suzuki HI, Mihira H, Watabe T, Sugimoto K, Miyazono K. (2013) Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis. Nucleic Acids Research. 41:e62.

    2012

    1. Takaesu NT, Stinchfield MJ, Shimizu K, Arase M, Quijano JC, Watabe T, Miyazono　K, Newfeld SJ. (2012) Drosophila CORL is required for Smad2-mediated activation of　Ecdysone Receptor expression in the mushroom body. Development. 139:3392-3401.
    2. Kawata M, Koinuma D, Ogami T, Umezawa K, Iwata C, Watabe T, Miyazono K. (2012) TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. Journal of Biochemistry. 151:205-216.
    3. Mihira H, Suzuki HI, Akatsu Y, Yoshimatsu Y, Igarashi T, Miyazono K, Watabe T. (2012) TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. Journal of Biochemistry. 143:199-206.
    4. Watabe T. (2012) Roles of transcriptional network during the formation of lymphatic vessels. J Biochem. 152:213-220. (Review)
    5. Watabe T. (2012) Roles of Dppa2 in the regulation of the present status and future of pluripotent stem cells. J Biochem. 152:1-3. (Commentary)

    2011

    1. Azuma K, Urano T, Watabe T, Ouchi Y, Inoue S. (2011) PROX1 suppresses vitamin K-induced transcriptional activity of Steroid and Xenobiotic Receptor. Genes to Cells. 16:1063-1070.
    2. Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, Harada K, Morikawa M, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T. (2011) Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. Journal of Cell Science. 124:2753-2762.
    3. Takahashi S, Watanabe T, Okada M, Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, Kato S. (2011) Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A. 108: 4938-4943.
    4. Yoshimatsu Y, Watabe T. (2011) Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fibrosis. Int J Inflam. 2011:724080. (Review)
    5. Watabe T. (2011) Roles of old players in the suppression of a new player: networks for the transcriptional control of angiogenesis. J Biochem. 149: 117-119. (Commentary)

    〜2010

    1. Suzuki Y, Ohga N, Morishita Y, Hida K, Miyazono K, Watabe T. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. Journal of Cell Science. 123:1684-1692.
    2. Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K. (2009) Identification of Prox1 targets during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. Journal of Cell Science. 122: 3923-3930.
    3. Yamamizu K, Kawasaki K, Katayama S, Watabe T, Yamashita JK. (2009) Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and neuropilin-1. Blood. 114: 3707-3716.
    4. Sase H, Watabe T, Kawasaki K, Miyazono K, Miyazawa K. (2009) VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells. Journal of Cell Science. 122:3303-3311.
    5. Saito RA, Watabe T, Horiguchi K, Kohyama T, Saitoh M, Nagase T, Miyazono K. (2009) TTF-1 inhibits TGF-β mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells. Cancer Research. 69:2783-2791.
    6. Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T. (2009) COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes to Cells. 14:425-434.
    7. Watabe T, Miyazono K. (2009) Roles of TGF-β family signaling in stem cell renewal and differentiation. Cell Research. 19:103-115. (Review)
    8. Katsu M, Koyama H, Maekawa H, Kurihara H, Uchida H, Hamada H. (2009) Ex vivo gene delivery of ephrin-B2 induces development of functional collateral vessels in a rabbit model of hind limb ischemia. Journal of Vascular Surgery. 49:192-198.
    9. Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, * Watabe T (*: corresponding author), Miyazono K. (2008) Snail is required for TGF-β induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. Journal of Cell Science. 121:3317-3324.
    10. Nonaka H, Watabe T, Saito S, Miyazono K, Miyajima A. (2008) Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGF-β /activin signaling. Biochemical and Biophysical Research Communications. 375:256-260.
    11. Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K. (2008) Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. Journal of Cell Biology. 181:131-141.
    12. Oka M, Iwata C, Suzuki H, Kiyono K, Morishita Y, Watabe T, Komuro A, Kano MR, Miyazono K. (2008) Inhibition of endogenous TGF-β signaling enhances lymphangiogenesis. Blood. 111:4571-4579.
    13. Suzuki Y, Montagne K,Nishihara A, * Watabe T (*: corresponding author), Miyazono K. (2008) BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and Angiopoietin-1/Tie2 signals. Journal of Biochemistry. 143:199-206.
    14. Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P. (2008) Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. Prostate. 68:139-151.
    15. Watabe T, Miyazono K. (2008) TGF- family signaling in stem cell renewal and differentiation. The TGF- Family. (Cold Spring Harbor Laboratory Press) 585-612. (Review)
    16. Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K. (2007) Prox1 induces lymphatic endothelial differentiation via integrin β9 and other signaling cascades. Molecular Biology of the Cell. 18:1421-1429.
    17. Ogawa K, Saito A, Matsui H, Suzuki H, Ohtsuka S, Shimosato D, Morishita Y, Watabe T, Niwa H, Miyazono K. (2007) Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. Journal of Cell Science. 120:55-65.
    18. Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S, Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, and Horie S (2005) Effect of Smad7 Expression on Metastasis of Mouse Mammary Carcinoma JygMC(A) Cells. Journal of National Cancer Institute. 97:1734-1746.
    19. Watabe T, Mishima K, Yamashita J, and Miyazono K. (2006) TGF-β signaling in embryonic stem cell-derived endothelial cells (book chapter). Embryonic Stem Cells-II: Methods and Protocols (Humana Press) 330:341-351. (Review)
    20. Kano MR, Morishita Y, Iwata C, Iwasaka S, Watabe T, Ouchi Y, Miyazono K, Miyazawa K. (2005) VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRβ signaling. Journal of Cell Science. 118:3759-3768.
    21. Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JK, Obi S, Ohura N, Matsushita A, Kamiya A, Ando J (2005) Fluid Shear Stress Induces Differentiation of Flk-1-Positive Embryonic Stem Cells into Vascular Endothelial Cells In Vitro. American Journal of Physiology - Heart and Circulatory Physiology. 288:915-924.
    22. Suzuki H, Watabe T, Miyazawa K, Kato M, and Miyazono K. (2005) Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Blood. 105:2372-2379.
    23. Miyazaki H, Watabe T, Kitamura T, and Miyazono K. (2004) BMP Signals Inhibit Proliferation and In Vivo Tumor Growth of Androgen Insensitive Prostate Carcinoma Cells. Oncogene. 23:9326-9335.
    24. Mochizuki T, Miyazaki H, Hara T, Furuya T, Imamura T, Watabe T, Miyazono K. (2004) Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-β superfamily signaling. Journal of Biological Chemistry. 279: 31568-31574.
    25. Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T. (2004) USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochemical and Biophysical Research Communications. 316:490-500.
    26. Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K. (2004) Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Molecular Biology of the Cell. 15:963-972.
    27. Okumura E, Fukuhara T, Yoshida H, Hanada S, Kozutsumi R, Mori M, Tachibana K, Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa SI, and Miyazono K. (2003) TGF- receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. Journal of Cell Biology. 163:1303-1311.
    28. Takebayashi-Suzuki K, Funami J, Tokumori D, Saito A, Watabe T, Miyazono K, Kanda A, and Suzuki A. (2003) Interplay between the tumor suppressor p53 and TGF-β signaling shapes embryonic body axes in Xenopus. Development. 130:3929-3939.
    29. Murakami G, Watabe T, Takaoka T, Miyazono K and Imamura T. (2003) Multi-step Inhibition of BMP Signaling by Smurf1. Molecular Biology of the Cell. 14:2809-2817.
    30. Nishihara A, Watabe T, Imamura T, Miyazono K. (2002) Functional Heterogeneity of Bone Morphogenetic Protein Receptor-II Mutants Found in Patients with Primary Pulmonary Hypertension. Molecular Biology of the Cell. 13:3055-3063.
    31. Watabe T, Lin M, Reiter RE, Witte ON. (2001) Growth, Regeneration and Tumorigenesis of the Prostate Activates the PSCA Promoter. Proceedings of National Academy of Sciences U.S.A. 99:401-406.
    32. Mochizuki T, Karavanov AA, Curtiss PE, Ault KT, Sugimoto N, Watabe T, Shiokawa K, Jamrich M, Cho KW, Dawid IB, Taira M. (2000) Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. Developmental Biology. 224:470-485.
    33. Reiter RE, Sato I, Thomas G, Qian J, Gu Z, Watabe T, Loda M, Jenkins RB. (2000) Coamplification of prostate stem cell antigen (PSCA) and MYC in locally advanced prostate cancer. Genes, Chromosomes and Cancer. 27:95-103.
    34. Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. (1998) Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proceedings of National Academy of Sciences U.S.A. 95:1735-1740.
    35. *Candia AF, *Watabe T (*: contributed equally), Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW. (1997) Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development. 124:4467-4480.
    36. Watabe T., Candia, A., Cho, KW. (1997). Activin signaling pathways and their role in Xenopus mesoderm formation. (book chapter).“Inhibin, activin and follistatin”. Serano Symposium. Springer-Verlag, NY. (Review)
    37. Watabe T, Kim S, Candia A, Rothbacher U, Hashimoto C, Inoue K, Cho KW. (1995) Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes & Development. 9:3038-3050.
    38. Hawley SH, Wunnenberg-Stapleton K, Hashimoto C, Laurent MN, Watabe T, Blumberg BW, Cho KW. (1995) Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes & Development. 9:2923-2935.
    39. Rothbacher U, Laurent MN, Blitz IL, Watabe T, Marsh JL, Cho KW. (1995) Functional conservation of the Wnt signaling pathway revealed by ectopic expression of Drosophila dishevelled in Xenopus. Developmental Biology. 170:717-721

  • 2024

    2023

    1. Terasawa K, Seike T, Sakamoto K, Ohtake K, Terada T, Iwata T, Watabe T, Yokoyama S, *Hara-Yokoyama M. Site-specific photo-crosslinking/cleavage for protein-protein interface identification reveals oligomeric assembly of lysosomal-associated membrane protein type 2A in mammalian cells. Protein Science. 2023 Dec;32(12):e4823. doi: 10.1002/pro.4823. [Pubmed]
    2. Terasawa K, Seike T, Sakamoto K, Ohtake K, Terada T, Iwata T, Watabe T, Yokoyama S, *Hara-Yokoyama M. Site-specific photo-crosslinking/cleavage for protein-protein interface identification reveals oligomeric assembly of lysosomal-associated membrane protein type 2A in mammalian cells. Protein Science. 2023 Dec;32(12):e4823. doi: 10.1002/pro.4823. [Pubmed]

    2022

    2021

    1. Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells. Kazue Terasawa, Yuji Kato, Yuta Ikami, Kensaku Sakamoto, Kazumasa Ohtake, Seisuke Kusano, Yuri Tomabechi, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Jun-Lin Guan, Toshihide Kobayashi, Takanori Iwata, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama. Autophagy . 2021 Dec;17(12):4286-4304. doi: 10.1080/15548627.2021.1911017.Epub 2021 Apr 14.[Pubmed]

    2020

    1. Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis.Yamamoto D, Kayamori K, Sakamoto K, Tsuchiya M, Ikeda T, Harada H, Yoda T, Watabe T, Hara-Yokoyama M .Cancer Sci . 2020 Feb;111(2):700-712. doi: 10.1111/cas.14249. Epub 2019 Dec 20.PMID:31769164 [Pubmed]
    2. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Kato Y,Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T, Hara-Yokoyama M . Bioorg Med Chem Lett . 2020 Feb 1;30(3):126891. doi: 10.1016/j.bmcl.2019.126891. Epub 2019 Dec 17.PMID:31874824 [Pubmed]

    2019

    1. Yamamoto D, Kayamori K, Sakamoto K, Tsuchiya M, Ikeda T, Harada H, Yoda T, Watabe T, Hara-Yokoyama M .Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis. Cancer science . 2019 nov . [Pubmed]
    2. Hara-Yokoyama M, Kurihara H, Ichinose S, Matsuda H, Ichinose S, Kurosawa M, Tada N, Iwahara C, Terasawa K, Podyma-Inoue KA , Furukawa K, Iwabuchi K. KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2019 nov 67(11) 813-824 [Pubmed]
    3. Kato Y, Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T, Hara-Yokoyama M .The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorganic & medicinal chemistry letters .126891 2019 dec. [Pubmed]

    2018

    1. Inokuchi JI, Ode T, Hara-Yokoyama M . Pharmacological Modulation of Glycosphingolipid Metabolism. Methods Mol Biol. 2018;1804:401-410. doi:10.1007/978-1-4939-8552-4_19. [Pubmed] PMID: 29926420.

    2017

    1. Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, Hara-Yokoyama M. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
      Exp Cell Res. 2017 Jan 1;350(1):103-114. doi: 10.1016/j.yexcr.2016.11.011. Epub 2016 Nov 16.[Pubmed]

    2016

    1. Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Katarzyna A Podyma-lnoue, Anupama R Rajapakshe,Watabe T, Shirouzu M, Hara-Yokoyama M. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016 Jan. O; 479(3); 489-495[Pubmed]
    2. Katarzyna A Podyma-lnoue. Moriwaki T, Anupama R Rajapakshe, Terasawa K, Hara-Yokoyama M. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016 Dec.; 13(6); 443-452[Pubmed]

    2015

    1. Terasawa K, Rajapakshe AR, Podyma-Inoue KA, Mishima-Tsumagari C, Yanagishita M, Hara-Yokoyama M. (2015) Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL. J Immunol Methods. 420:1-10. (Epub 2015 Mar 13.)[Pubmed]

    2014

    1. Rajapakshe AR, Podyma-Inoue KA, Terasawa K, Hasegawa K, Namba T, Kumei Y, Yanagishita M, Hara-Yokoyama M. (2015) Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. Exp Cell Res. 331(1):211-22. (Epub 2014 Sep 22.)[Pubmed]

    2013

    1. Hara-Yokoyama M, Terasawa K, Ichinose S, Watanabe A, Podyma-Inoue KA, Akiyoshi K, Igarashi Y, Yanagishita M. (2013) Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. Bioorg Med Chem Lett. 23(7):2220-4. (Epub 2013 Jan 30.)
    2. Hara-Yokoyama M. (2013) Glycosylation Regulates CD38 Assembly on the Cell Surface. Trends in Glycoscience and Glycotechnology 25:215-225

    2012

    1. Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M. (2012) Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities. Structure. 20(9):1585-95. (Epub 2012 Aug 2.)
    2. Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Ikutani M, Takaki S, Sakamoto K, Hara-Yokoyama M, Shirouzu M, Takatsu K, Yokoyama S. (2012) Structural basis of interleukin-5 dimer recognition by its α receptor. Protein Sci. 21(6):850-64.( Epub 2012 Apr 23.)
    3. Podyma-Inoue KA, Hara-Yokoyama M, Shinomura T, Kimura T, Yanagishita M. (2012) Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. PLoS One. 7(3):e32351. (Epub 2012 Mar 1.)

    2011

    1. Ebe N, Hara-Yokoyama M, Iwasaki K, Iseki S, Okuhara S, Podyma-Inoue KA, Terasawa K, Watanabe A, Akizuki T, Watanabe H, Yanagishita M, Izumi Y. (2011)Pocket epithelium in the pathological setting for HMGB1 release. J Dent. Res. 90(2):235-40. (Epub 2010 Dec 13.)

    〜2010

    1. Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato C, Kitajima K, Ogawa H. (2010) Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. J. Biol. Chem. 285, 17301-17309.
    2. Yanagishita M, Podyma-Inoue KA, Yokoyama M. (2009) Extraction and separation of proteoglycans. Glycoconjugate Journal 26, 953-9
    3. Hara-Yokoyama M, Kimura T, Kaku H, Wakiyama M, Kaitsu Y, Inoue M, Kusano S, Shirouzu M, Yokoyama S, Katada T, Hirabayashi Y, Takatsu K, Yanagishita M. (2008) Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation. Int Immunopharmacol. 8(1):59-70. (Epub 2007 Nov 1.)
    4. Katsumata O, Fujita-Yoshigaki J, Hara-Yokoyama M, Yanagishita M, Furuyama S, Sugiya H. (2007) Syntaxin6 separates from GM1a-rich membrane microdomain during granule maturation. Biochem Biophys Res Commun. 357(4):1071-7. (Epub 2007 Apr 18.)
    5. Hara-Yokoyama M. (2006) Gangliosides potentially inhibit extracellular nucleotide metabolism. Curr Med Chem. 13(19):2233-9. Review.
    6. Ueno-Noto K, Hara-Yokoyama M, Takano K. (2006) Recognition of tandem sialic acid residues by CD38: a theoretical study. J Comput Chem. 15;27(1):53-60.
    7. Katsumata O, Kimura T, Nagatsuka Y, Hirabayashi Y, Sugiya H, Furuyama S, Yanagishita M, Hara-Yokoyama M. (2004) Charge-based separation of detergent-resistant membranes of mouse splenic B cells. Biochem Biophys Res Commun. 319(3):826-31.
    8. Hara-Yokoyama M, Ito H, Ueno-Noto K, Takano K, Ishida H, Kiso M. (2003) Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38. Bioorg Med Chem Lett. 13(20):3441-5.
    9. Nagatsuka Y, Hara-Yokoyama M, Kasama T, Takekoshi M, Maeda F, Ihara S, Fujiwara S, Ohshima E, Ishii K, Kobayashi T, Shimizu K, Hirabayashi Y. (2003) Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells. Proc Natl Acad Sci U S A. 100(13):7454-9. (Epub 2003 Jun 11.)
    10. Dohke Y, Fujita-Yoshigaki J, Sugiya H, Furuyama S, Hara-Yokoyama M. (2002) Involvement of phospholipase D in the cAMP-regulated exocytosis of rat parotid acinar cells. Biochem Biophys Res Commun. 299(4):663-8.
    11. Katsumata O, Hara-Yokoyama M, Sautès-Fridman C, Nagatsuka Y, Katada T, Hirabayashi Y, Shimizu K, Fujita-Yoshigaki J, Sugiya H, Furuyama S. (2001) Association of FcgammaRII with low-density detergent-resistant membranes is important for cross-linking-dependent initiation of the tyrosine phosphorylation pathway and superoxide generation. J Immunol. 167(10):5814-23.
    12. Sugiya H, Mitsui Y, Michikawa H, Fujita-Yoshigaki J, Hara-Yokoyama M, Hashimoto S, Furuyama S. (2001) Ca(2+)-regulated nitric oxide generation in rabbit parotid acinar cells. Cell Calcium. 30(2):107-16.
    13. Hara-Yokoyama M, Nagatsuka Y, Katsumata O, Irie F, Kontani K, Hoshino S, Katada T, Ono Y, Fujita-Yoshigaki J, Sugiya H, Furuyama S, Hirabayashi Y. (2001) Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38. Biochemistry. 40(4):888-95.
    14. Kukimoto M, Nureki O, Shirouzu M, Katada T, Hirabayashi Y, Sugiya H, Furuyama S, Yokoyama S, Hara-Yokoyama M. (2000) Crystallization and preliminary X-ray diffraction analysis of the extracellular domain of the cell surface antigen CD38 complexed with ganglioside. J Biochem. 127(2):181-4.
    15. Fujita-Yoshigaki J, Dohke Y, Hara-Yokoyama M, Furuyama S, Sugiya H. (1999) Presence of a complex containing vesicle-associated membrane protein 2 in rat parotid acinar cells and its disassembly upon activation of cAMP-dependent protein kinase. J Biol Chem. 274(33):23642-6.
    16. Michikawa H, Mitsui Y, Fujita-Yoshigaki J, Hara-Yokoyama M, Furuyama S, Sugiya H. (1998) cGMP production is coupled to Ca(2+)-dependent nitric oxide generation in rabbit parotid acinar cells. Cell Calcium. 23(6):405-12.
    17. Sugiya H, Michikawa H, Mitsui Y, Fujita-Yoshigaki J, Hara-Yokoyama M, Furuyama S. (1998) Ca2+-nitric oxide-cGMP signaling in rabbit parotid acinar cells. Eur J Morphol. 36 Suppl:194-7. Review.
    18. Dohke Y, Hara-Yokoyama M, Fujita-Yoshigaki J, Furuyama S, Sugiya H. (1998) ADP-ribosylation factors in rat parotid acinar cells. Eur J Morphol. 36 Suppl:186-9. Review.
    19. Fujita-Yoshigaki J, Dohke Y, Hara-Yokoyama M, Furuyama S, Sugiya H. (1998) Snare proteins essential for cyclic AMP-regulated exocytosis in salivary glands. Eur J Morphol. 36 Suppl:46-9. Review.
    20. Dohke Y, Hara-Yokoyama M, Fujita-Yoshigaki J, Kahn RA, Kanaho Y, Hashimoto S, Sugiya H, Furuyama S. (1998) Translocation of Arf1 to the secretory granules in rat parotid acinar cells. Arch Biochem Biophys. 357(1):147-54.
    21. Fujita-Yoshigaki J, Dohke Y, Hara-Yokoyama M, Kamata Y, Kozaki S, Furuyama S, Sugiya H. (1996) Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis in rat parotid acinar cells. The inhibition of cAMP-dependent amylase release by botulinum neurotoxin B. J Biol Chem. 271(22):13130-4.
    22. Hara-Yokoyama M, Kukimoto I, Nishina H, Kontani K, Hirabayashi Y, Irie F, Sugiya H, Furuyama S, Katada T. (1996) Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides. J Biol Chem. 271(22):12951-5.
    23. Hara-Yokoyama M, Hirabayashi Y, Irie F, Syuto B, Moriishi K, Sugiya H, Furuyama S. (1995) Identification of gangliosides as inhibitors of ADP-ribosyltransferases of pertussis toxin and exoenzyme C3 from Clostridium botulinum. J Biol Chem. 270(14):8115-21.
    24. Hara-Yokoyama M, Sugiya H, Furuyama S, Wang JH, Yokoyama N. (1994) Dephosphorylation of ribosomal protein S6 phosphorylated via the cAMP-mediated signaling pathway in rat parotid gland: effect of okadaic acid and Zn2+. Biochem Mol Biol Int. 34(6):1177-87.
    25. Hara-Yokoyama M, Sugiya H, Furuyama S. (1994) Possible involvement of adenylylation in the modification of a 26 kDa protein in rat parotid acinar cells. Int J Biochem. 26(9):1103-9.
    26. Yokoyama N, Hara-Yokoyama M, Kobayashi T, Tamura S, Furuyama S, Sugiya H. (1994) Involvement of type 2C phosphatase in the dephosphorylation of 26 kDa phosphoprotein in rat parotid acinar cells. Biochem Biophys Res Commun. 200(1):497-503.
    27. Sugiya H, Hara-Yokoyama M, Furuyama S. (1992) Isoproterenol-stimulated labelling of particulate proteins by using [adenylate-32P]NAD+ independent on a cAMP-dependent protein kinase in parotid acinar cells. FEBS Lett. 300(2):171-4.
    28. Nureki O, Suzuki K, Hara-Yokoyama M, Kohno T, Matsuzawa H, Ohta T, Shimizu T, Morikawa K, Miyazawa T, Yokoyama S. (1992) Glutamyl-tRNA synthetase from Thermus thermophilus HB8. Molecular cloning of the gltX gene and crystallization of the overproduced protein. Eur J Biochem. 204(2):465-72.
    29. Haruki M, Matsumoto R, Hara-Yokoyama M, Miyazawa T, Yokoyama S. (1990) Conformational changes of aminoacyl-tRNA and uncharged tRNA upon complex formation with polypeptide chain elongation factor Tu. FEBS Lett. 263(2):361-4.
    30. Hara-Yokoyama M, Furuyama S. (1989) An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain. Biochem Biophys Res Commun. 160(1):67-71.
    31. Hara-Yokoyama M, Furuyama S. (1988) Endogenous inhibitor of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin is present in rat liver. FEBS Lett. 234(1):27-30.
    32. Hara-Yokoyama M, Yokoyama S, Miyazawa T. (1986) Conformation change of tRNAGlu in the complex with glutamyl-tRNA synthetase is required for the specific binding of L-glutamate. Biochemistry. 25(22):7031-6.
    33. Yokoyama S, Haruki M, Hara-Yokoyama M, Miyazawa T. (1986) Circular dichroism analyses of tRNA X protein interactions. Nucleic Acids Symp Ser. 1986;(17):199-201.
    34. Horie N, Hara-Yokoyama M, Yokoyama S, Watanabe K, Kuchino Y, Nishimura S, Miyazawa T. (1985) Two tRNAIle1 species from an extreme thermophile, Thermus thermophilus HB8: effect of 2-thiolation of ribothymidine on the thermostability of tRNA. Biochemistry. 24(21):5711-5.
    35. Hara-Yokoyama M, Yokoyama S, Miyazawa T. (1984) Purification and characterization of glutamyl-tRNA synthetase from an extreme thermophile, Thermus thermophilus HB8. J Biochem. 96(5):1599-607.

  • 2024

    1. Takahashi K, Kobayashi M, Katsumata H, Tokizaki S, Anzai T, Ikeda Y, Alcaide DM, Maeda K, Ishihara M, Tahara K, Kubota Y, Itoh F, Park J, Takahashi K, Matsunaga YT, Yoshimatsu Y, Podyma-Inoue KA, *Watabe T. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023 Dec 18. doi: 10.1111/cas.16045. Epub ahead of print. [Pubmed]
    2. Tokizaki S, Podyma-Inoue KA, Matsumoto T, Takahashi K, Kobayashi M, Ibi H, Uchida S, Iwabuchi S, Harada H, Hashimoto S, Miyazono K, *Watabe T. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023 Nov 16. doi: 10.1111/cas.16006. Epub ahead of print. [Pubmed]

    2023

    2022

    2021

    1. Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Sakakitani S, Podyma-Inoue KA, Takayama R, Takahashi K, Ishigami-Yuasa M, Kagechika H, Harada H, Watabe T. Cancer Sci . 2020 Oct 2;112(1):155-67. doi: 10.1111/cas.14670. Online ahead of print.PMID: 33007125[Pubmed]
    2. Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor Kodama S, Podyma-Inoue KA, Uchihashi T, Kurioka K, Takahashi H, Sugauchi A, Takahashi K, Inubushi T, Kogo M, Tanaka S, Watabe T. Oncol Rep . 2021 Sep;46(3):197. doi: 10.3892/or.2021.8148. Epub 2021 Jul 23.[Pubmed]

    2020

    1. Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Yang W, Podyma-Inoue KA , Yonemitsu I, Watari I, Ikeda Y, Guo X, Watabe T, Ono T. Clin Oral Investig .2020 Feb 7. doi: 10.1007/s00784-020-03225-4. Online ahead of print.PMID: 32034544 [Pubmed]
    2. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals. Yoshimatsu Y, Kimuro S, Pauty J, Takagaki K, Nomiyama S, Inagawa A, Maeda K,Podyma-Inoue KA ,Kajiya K, Matsunaga YT, Watabe T.PLoS One . 2020 May 1;15(5):e0232356. doi: 10.1371/journal.pone.0232356. eCollection 2020.PMID: 32357159 [Pubmed]
    3. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M , Maishi N, Podyma-Inoue KA , Hida K, Miyazono K, Watabe T. Cancer Sci . 2020 May 9. doi: 10.1111/cas.14455. Online ahead of print .PMID: 32385953 [Pubmed]
    4. Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. Takahashi K, Akatsu Y, Podyma-Inoue KA , Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T. J Biol Chem . 2020 Jul 6:jbc.RA120.012492. doi: 10.1074/jbc.RA120.012492. Online ahead of print.PMID: 32631954[Pubmed]

    2019

    1. Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma.Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T.Sci Rep. 2019 Feb 4;9(1):1281. doi: 10.1038/s41598-019-39018-3.[Pubmed]
    2. Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae. Ren E, Watari I, Jui-Chin H, Mizumachi-Kubono M, Podyma-Inoue KA, Narukawa M, Misaka T, Watabe T, Ono T.Acta Histochem. 2019 Feb;121(2):135-142. doi: 10.1016/j.acthis.2018.10.007. Epub 2018 Nov 23. [Pubmed]

    2018

    1. Takahashi K, Podyma-Inoue KA , Takao C, Yoshimatsu Y, Muramatsu T,Inazawa J, Watabe T. Regulatory role of transforming growth factor-βsignals in the migration and tumor formation of HOC313-LM cells, anoral squamous cell carcinoma.The Journal of theStomatological Society, 85: 52-61, 2018

    2017

    1. Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA,
      Watabe T, Sato Y. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling.
      Cancer Sci. 2017 Mar;108(3):419-426. doi: 10.1111/cas.13157.[Pubmed]
    2. Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, Hara-Yokoyama M. PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
      Exp Cell Res. 2017 Jan 1;350(1):103-114. doi: 10.1016/j.yexcr.2016.11.011. Epub 2016 Nov 16.[Pubmed]

    2016

    1. Terasawa K, Tomabechi Y, Ikeda M, Ehara H, Kukimoto-Niino M, Wakiyama M, Podyma-Inoue KA, Anupama R Rajapakshe,Watabe T, Shirouzu M, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun.. 2016 Jan. O; 479(3); 489-495[Pubmed]
    2. Podyma-Inoue KA. Moriwaki T, Anupama R Rajapakshe, Terasawa K, Hara-Yokoyama M. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016 Dec.; 13(6); 443-452[Pubmed]

    2015

    1. Watari I, Abbassy MA, Podyma-Inoue KA and Ono T (2015). Complication of Type 1 Diabetes in Craniofacial and Dental Hard Tissue, Major Topics in Type 1 Diabetes, Dr. Kenia Nunes (Ed.), ISBN: 978-953-51-2204-3, InTech, DOI: 10.5772/61885. Available from: http://www.intechopen.com/books/major-topics-in-type-1-diabetes/complication-of-type-1-diabetes-in-craniofacial-and-dental-hard-tissue (book chapter)
    2. Terasawa K, Rajapakshe AR, Podyma-Inoue KA, Mishima-Tsumagari C, Yanagishita M, Hara-Yokoyama M. Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL. (2015) Journal of Immunological Methods. 420:1-10[Pubmed]
    3. Rajapakshe AR*, Podyma-Inoue KA*, Terasawa K, Hasegawa K, Namba T, Yasuhiro Kumei Y, Yanagishita M, Hara-Yokoyama M. Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. (2015) Experimental Cell Research. 331:211-222. (*equally contributed)[Pubmed]

    2014

    1. Aoyama E, Watari I, Podyma-Inoue KA, Yanagishita M, Ono T. Expression of glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells. (2014) International Journal of Molecular Medicine. 34: 475-482.[Pubmed]
    2. Ippei W, Privatananupunt J, Jui-Chin H, Podyma-Inoue KA, Aoyama E and Ono T. (2014) The influence of gestational diabetes in craniofacial growth of newborn rat Journal of Society for Women's Health Science Research. 3: 57-62
    3. Privatananupunt J, Watari I, Podyma-Inoue KA, Kubono M, Ono T. Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands. (2014) Acta Histochemica. 116: 545-550.[Pubmed]

    2013

    1. Kasekarn K, Podyma-Inoue KA and Yanagishita M. Effect of lipopolysaccharide from Porphyromonas gingivalis on expression of heparanase in human gingival epithelial cell line, Ca9-22. (2013) Chulalongkorn University Dental Journal. 36: 143-152.
    2. Takehara S, Yanagishita M, Podyma-Inoue KA, Kawaguchi Y. Degradation of MUC7 and MUC5B in human saliva. (2013) PLoS ONE. 8: e69059.[Pubmed]
    3. Hara-Yokoyama M, Terasawa K, Ichinose S, Watanabe A, Podyma-Inoue KA, Akiyoshi K, Igarashi Y, Yanagishita M. Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. (2013) Bioorganic and Medicinal Chemistry Letters. 23: 2220-2224. [Pubmed]

    2012

    1. Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M. Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities. (2012) Structure. 20: 1585-1595.[Pubmed]
    2. Podyma-Inoue KA, Hara-Yokoyama M, Shinomura T, Kimura T, Yanagishita M. Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line. (2012) PLoS ONE. 7: e32351.[Pubmed]

    2011

    1. Ebe N, Hara-Yokoyama M, Iwasaki K, Iseki S, Okuhara S, Podyma-Inoue KA, Terasawa K, Watanabe A, Akizuki T, Watanabe H, Yanagishita M, Izumi Y. Pocket epithelium in the pathological setting for HMGB1 release. (2011) Journal of Dental Research. 90: 235-240.[Pubmed]

    ～2010

    1. Takehara S, Yanagishita M, Podyma-Inoue KA, Ueno M, Shinada K, Kawaguchi Y. Relationship between oral malodor and glycosylated salivary proteins. (2010) Journal of Medical and Dental Sciences. 57: 25-33.[Pubmed]
    2. Yanagishita M, Podyma-Inoue KA, Yokoyama M. Extraction and separation of proteoglycans. (2009) Glycoconjugate Journal. 26: 953-959.[Pubmed]
    3. Yanagishita M, Podyma-Inoue KA. Golgi and Lysosomal Disease: Degradation of hyaluronan and its disorder (2008) Taniguchi N, Suzuki A, Ito A, Narimatsu H, Kawasaki T, Hase S (Eds.). Experimental Glycoscience: Glycobiology. P216-218. Springer. ISBN: 978-4-431-77921-6, DOI: 10.1007/978-4-431-77922-3, (book section).[Springer Link]
    4. Tsuchida S, Podyma-Inoue KA, Yokoyama M, Fukasawa K, Ishihara A, Yanagishita M, Yoshinari N. Use of proteomics in research on periodontal disease. (2007) Journal of the Japanese Society of Periodontology. 49: 257-263.
    5. Yanagishita M, Tsuchida S, Yokoyama M, Inoue KA. Effect of p-nitrophenyl-xyloside on the biosynthesis of proteoglycan in rat ovarian granulosa cells--analyses of glycosaminoglycan synthesis in the Golgi apparatus. (2006) Kokubyo Gakkai Zasshi 73: 20-25.[Pubmed]
    6. Dias RA, Shibata S, Hashimoto-Uoshima M, Podyma-Inoue KA, Ishikawa I, Yanagishita M. Syndecan-1 expression during the formation of junctional epithelium. (2005) Journal of Periodontology. 76: 696-704.[Pubmed]
    7. Ozaki S, Kaneko S, Podyma-Inoue KA, Yanagishita M, Soma K. Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress. (2005) Journal of Periodontal Research. 40:110-7.[Pubmed]
    8. Tsuchida S, Podyma-Inoue KA, Yanagishita M. Ultrafiltration-based assay for heparanase activity. (2004) Analytical Biochemistry. 331: 147-152.[Pubmed]
    9. Hashimoto-Uoshima M, Dias RA, Noguchi K, Podyma KA, Yanagishita M and Ishikawa I. Effects of cytokines on proteoglycan biosynthesis in human periodontal tissue cells (2004) The Japanese Journal of Conservative Dentistry. 47: 684-695.
    10. Kurokawa K, Katsube K, Podyma KA, Ikuta M, Iseki H, Nakajima M, Akashi T, Omura K, Takagi M, Yanagishita M. Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts. (2003) Cancer Science. 94: 277-285. [Pubmed]
    11. Podyma-Inoue KA, Yokote H, Sakaguchi K, Ikuta M, Yanagishita M. Characterization of heparanase from a rat parathyroid cell line. (2002) Journal of Biological Chemistry. 277: 32459-32465.[Pubmed]
    12. Ikuta M, Podyma KA, Maruyama K, Enomoto S, Yanagishita M. Expression of heparanase in oral cancer cell lines and oral cancer tissues. (2001) Oral Oncology. 37: 177-184.[Pubmed]
    13. Podyma KA, Yamagata S, Sakata K, Yamagata T. Difference of hyaluronidase produced by human tumor cell lines with hyaluronidase present in human serum as revealed by zymography. (1997) Biochemical and Biophysical Research Communications. 241: 446-452.[Pubmed]

  • 2024

    1. Takahashi K, Kobayashi M, Katsumata H, Tokizaki S, Anzai T, Ikeda Y, Alcaide DM, Maeda K, Ishihara M, Tahara K, Kubota Y, Itoh F, Park J, Takahashi K, Matsunaga YT, Yoshimatsu Y, Podyma-Inoue KA, *Watabe T. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023 Dec 18. doi: 10.1111/cas.16045. Epub ahead of print. [Pubmed]
    2. Tokizaki S, Podyma-Inoue KA, Matsumoto T, Takahashi K, Kobayashi M, Ibi H, Uchida S, Iwabuchi S, Harada H, Hashimoto S, Miyazono K, *Watabe T. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023 Nov 16. doi: 10.1111/cas.16006. Epub ahead of print. [Pubmed]

    2023

    2022

    2021

    1. Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors. Kobayashi M, Wakabayashi I, Suzuki Y, Fujiwara K, Nakayama M, Watabe T, Sato Y. Angiogenesis . 2020 Oct 14. doi: 10.1007/s10456-020-09754-6. Online ahead of print.PMID: 33052495[Pubmed]

    2020

    1. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M , Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. Cancer Sci . 2020 May 9. doi: 10.1111/cas.14455. Online ahead of print .PMID: 32385953 [Pubmed]

    2019

    2016

    1. Kobayashi M, Suzuki Y, Sato Y.The post‐translational modification of microtubules mediates.The American Society th for Cell Biology 56th Annual Meeting. 2016 dec. p383.
    2. Phowichit S,Kobayashi M, Fujinoya Y, Sato Y, Sanphanya K, Vajragupta O, Chularojmontri L, Wattanapitayakul SK.Antiangiogenic Effects of VH02, a Novel Urea Derivative: In Vitro and in Vivo Studies.Molecules.2016 sep.21(9) 1258 [Pubmed]
    3. Horie S, Suzuki Y, Kobayashi M, Kadonosono T, Kizaka-Kondoh S, Kodama T, Sato Y.Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis.Cancer Gene therapy. 2016 may. 23(5) 133-141 [Pubmed]

    2014

    1. Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, Yaegashi N, Sato Y.The angiogenic factor, VASH2 regulate placental morphogenesis with the control of cell fusion.PLACENTA.2014 oct . 35(10) A19
    2. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation.Suenaga K, Kitahara S, Suzuki Y,Kobayashi M, Horie S, Sugawara J, Yaegashi N, Sato Y.Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation.PLoS One .2014 sep. 9(9) e104728 [Pubmed]
    3. Koyanagi T, Suzuki Y,Kobayashi M, Miyashita H, Saga Y, Suzuki M, Sato Y.Development of a novel anti-angiogenic cancer therapy targeting vasohibin-2.Angioenesis. 2014 jul 17(3) 751

    2013

    1. Ito S, Miyashita H, Suzuki Y,Kobayashi M, Satomi S, Sato Y.Enhanced cancer metastasis in mice deficient in vasohibin-1 gene.PLoS One.2013 sep. 8(9) e73931

    〜2010

    1. Suzuki Y, Kobayashi M, Miyashita H, Ohta H, Sonoda H, Sato Y. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion.Journal of Cell Science . 2010 sep. 123 3094-3101
    2. Kimura H, Miyashita H, Suzuki Y,Kobayashi M , Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T, Sato Y.Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis.Blood. 2009 may 113 4810-4818
    3. Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K.MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.The EMBO Journal. 2006 feb. 25 713-716
    4. Kobayashi M, Nishita M, Ohashi K, Mizuno K.VEGF-induced LIM Kinase 1 Phosphorylation and Activation are Required for Actin Cytoskeletal Reorganization and Migration of Endothelial Cell.The American Society th for Cell Biology 45th Annual Meeting. 637a 2005 dec

  • 2024

    1. Transforming growth factor-β signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis. Ibi H, Takahashi K, Harada H, Watabe T, Podyma-Inoue KA. Biochem Biophys Res Commun. 2024;714:149965. doi:10.1016/j.bbrc.2024.149965. PMID: 38657447 [Pubmed]
    2. Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters. Ikeda Y, Suehiro J, Oshima H, Kok SY, Takahashi K, Sakurai H, Watabe T, Oshima M, Matsunaga YT. bioRxiv. 2024. doi: https://doi.org/10.1101/2024.02.28.582606
    3. Takahashi K, Kobayashi M, Katsumata H, Tokizaki S, Anzai T, Ikeda Y, Alcaide DM, Maeda K, Ishihara M, Tahara K, Kubota Y, Itoh F, Park J, Takahashi K, Matsunaga YT, Yoshimatsu Y, Podyma-Inoue KA, *Watabe T. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023 Dec 18. doi: 10.1111/cas.16045. Epub ahead of print. [Pubmed]
    4. Tokizaki S, Podyma-Inoue KA, Matsumoto T, Takahashi K, Kobayashi M, Ibi H, Uchida S, Iwabuchi S, Harada H, Hashimoto S, Miyazono K, *Watabe T. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023 Nov 16. doi: 10.1111/cas.16006. Epub ahead of print. [Pubmed]

    2023

    1. Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system. Watabe T, Takahashi K, Pietras K, Yoshimatsu Y. Semin Cancer Biol. 2023 Jul;92:130-138. doi: 10.1016/j.semcancer.2023.04.007. [Pubmed]

    2022

    1. Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition. Kobayashi M, Fujiwara K, Takahashi K, Yoshioka Y, Ochiya T, Podyma-Inoue KA, Watabe T. Inflamm Regen. 2022 Sep 4;42(1):38. doi: 10.1186/s41232-022-00225-7. PMID: 36057626 [Pubmed]

    2021

    1. Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Sakakitani S, Podyma-Inoue KA, Takayama R, Takahashi K, Ishigami-Yuasa M, Kagechika H, Harada H, Watabe T. Cancer Sci. 2021 Jan;112(1):155-167. doi: 10.1111/cas.14670. Epub 2020 Nov 18. PMID: 33007125 [Pubmed]
    2. Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor. Kodama S, Podyma-Inoue KΑ, Uchihashi T, Kurioka K, Takahashi H, Sugauchi A, Takahashi K, Inubushi T, Kogo M, Tanaka S, Watabe T. Oncol Rep. 2021 Sep;46(3):197. doi: 10.3892/or.2021.8148. Epub 2021 Jul 23. PMID: 34296292 [Pubmed]

    2020

    1. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation. Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. Cancer Sci. 2020 Jul;111(7):2385-2399. doi: 10.1111/cas.14455. Epub 2020 Jun 11. PMID: 32385953 [Pubmed]
    2. Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. Takahashi K, Akatsu Y, Podyma-Inoue KA, Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T. J Biol Chem. 2020 Sep 4;295(36):12559-12572. doi: 10.1074/jbc.RA120.012492. Epub 2020 Jul 6. PMID: 32631954 [Pubmed]

    2019

    1. Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma. Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T. Sci Rep. 2019 Feb 4;9(1):1281. doi: 10.1038/s41598-019-39018-3. PMID: 30718742 [Pubmed]

    2018

    1. Takahashi K, Podyma-Inoue KA , Takao C, Yoshimatsu Y , Muramatsu T,Inazawa J, Watabe T. Regulatory role of transforming growth factor-βsignals in the migration and tumor formation of HOC313-LM cells, anoral squamous cell carcinoma.The Journal of theStomatologicalSociety, 85: 52-61, 2018

    2017

    1. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. Akatsu Y, Yoshimatsu Y, Tomizawa T, Takahashi K, Katsura A, Miyazono K, Watabe T. Cancer Sci. 2017 Jan;108(1):151-155. doi: 10.1111/cas.13103. PMID: 28133920 [Pubmed]
    2. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling. Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA, Watabe T, Sato Y. Cancer Sci. 2017 Mar;108(3):419-426. doi: 10.1111/cas.13157. PMID: 28064471 [Pubmed]
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