Ohata Y, Akiyama Y, Shimada S, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S .. Acquired resistance with epigenetic alterations under long-term antiangiogenic therapy for hepatocellular carcinoma Molecular Cancer Therapeutics, in press.
Oba A, Ban D, Kirimura S, Akahoshi K, Mitsunori Y, Matsumura S, Ochiai T, Kudo A, Tanaka S, Tanabe M .. Clinical application of the biomarkers for the selection of adjuvant chemotherapy in pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci., in press.
Ueda H, Ban D, Akahoshi K, Mitsunori Y, Matsumura S, Ochiai T, Kudo A, Tanaka S, Tanabe M. Refractory long-term cholangitis after pancreaticoduodenectomy: a retrospective study World Journal of Surgery, in press.
Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S . ARID2 modulates DNA damage response in human hepatocellular carcinoma cells Journal of Hepatology, in press.
Furuyama T, Kudo A, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Tanaka S, Tanabe M. Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy J Hepatobiliary Pancreat Sci .. 2016.12; 23(12); 763-770
Watanabe Y, Honda S, Konishi A, Satoko Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S. Autophagy controls centrosome number by degrading Cep63. Nature Communications. 2016.11; 21 (7); 13508
Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, Kano Y, Nishikawa S, Fukusumi T, Takahashi Y, Hata T, Nishimura J, Takemasa I, Mizushima T, lkenaga M, Kato T, Murata K, Carethers JM, Yamamoto H, Doki Y, Mori M. Cancer stem-like properties in colorectal cancer cells with low proteasome activity Clinical Cancer Research. 2016.11; 22(21); 5277-5286
Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardus A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paules M, Galan M, Sala N, Akiyama Y, Martfnez-lniesta M, Farre L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proceedings of the National Academy of Sciences of the United States of America. 2016.11; 113 (47); E7535-E7544
Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S. Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer. Oncotarget. 2016.1 O; 7(41); 67251-67265
Ojima F, Saito Y, Tsuchiya Y, Kayo D, Taniuchi S, Ogoshi M, Fukamachi H, Takeuchi S, Takahashi S. Runx3 transcription factor regulates ovarian functions and ovulation in female mice J Reprod Dev. 2016.10; 62(5); 479-486
Akahoshi K, Tanaka S, Mogushi K, Shimada S, Matsumura S, Akiyama Y, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, AriiS, Tanabe M. Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors. J. Gastroenterol .. 2016.09; 51 (9); 910-922
Eriko Katsuta, Atsushi Kudo, Takumi Akashi, Yusuke Mitsunori, Satoshi Matsumura, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Shinji Tanaka, Yoshinobu Eishi, Minoru Tanabe. Macroscopic morphology for estimation of malignant potential in pancreatic neuroendocrine neoplasm. J. Cancer Res. Clin. Oncol .. 2016.06; 142(6); 1299-1306
Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M. Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci Rep. 2016.05; 6; 27044
Lentjes MH, Niessen HE, Akiyama Y, de BruYne AP, Melotte V, van Engeland M. The emerging role of GATA transcription facto「s in development and disease. Expert Rev Mol Med. 2016.03; 18; e3
Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shinji Tanaka, Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Satoshi Otani, Miki Taniguchi, Fumio Goto, Hiroko Nagata, Shun Kaneko, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro ltsui, Mina Nakagawa, Minoru Tanabe, Shinichi Takano, Mitsuharu Fukasawa, Minoru Sakamoto, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J. Gastroenterol. 2016.03; 51 (5); 473-486
Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M .. CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. International Journal of Oncology . 2016.02; 48;657-669
Akiyama Y, Koda Y, Byeon SJ, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S. Reduced expression of SET7 /9, a histone mono-methyltransferase, is associated with gastric cancer progression. Oncotarget. 2016.01; 7 (4); 3966-3983
Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M. Dominant Expression of DCLKl in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis. PLoS ONE. 2016.01; 11 (1); eOl 46564
分子細胞機能学（中濱）
Yasuhiro Yoshimatsu, Hideki Miyazaki, Tetsuro Watabe. Roles of signaling and transcriptional
networks in pathological lymphangiogenesis. Adv. Drug Deliv. Rev .. 2016.04; 99(Pt B); 161-171
結合組織再生学（篠村）
Tani, H., Sato, Y., Ueda, M., Miyazaki, Y., Suginami, K., Horie, A., Konishi, I., and Shinomura, T .. Role of Versican in the Pathogenesis of Peritoneal Endometriosis The Journal of Clinical Endocrinology & Metabolism. 2016.11; 101 (11); 4349-4356
Nakayama Y, Kobayashi R, Matsui S, Matsumura H, lwai Y, Noda K, Yamazaki M, Kurita-Ochiai T, Yoshimura A, Shinomura T, Ganss B, Ogata Y .. Localization and expression pattern of amelotin, odontogenic ameloblast-associated protein and follicular dendritic cell-secreted protein in the junctional epithelium of inflamed gingiva Odontology. 2016.11;
K, Ito, T. Shinomura. Development and application of a new silent reporter system to quantitate the activity of enhancer elements in the type II collagen gene Gene. 2016.03; 585; 13-21
硬組織病態生化学（渡部）
Y Kumei, R Shimokawa, M Kimoto, Y Kawauchi, H Shimokawa, K Makita, K Ohya, K Toda. Gravity stress elevates the nociceptive threshold level with immunohistochemical changes in the rat brain. Acta Astronaut. 49(3-1 O); 381-390
Katarzyna A Podyma-lnoue, Takuya Moriwaki, Anupama R Rajapakshe, Kazue Terasawa, Miki Hara- Yokoyama. Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells. Cancer Genomics Proteomics. 2016.12; 13(6); 443-452
Kazue Terasawa, Yuri Tomabechi, Mariko Ikeda, Haruhiko Ehara, Mutsuko Kukimoto-Niino, Motoaki Wakiyama, Katarzyna A Podyma-lnoue, Anupama R Rajapakshe, Tetsuro Watabe, Mikako Shirouzu, Miki Hara-Yokoyama. Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. Biochem. Biophys. Res. Commun .. 2016.1 O; 479(3); 489-495
Kyohei Muguruma, Fumika Yakushiji, Ryosuke Kawamata, Daichi Akiyama, Risako Arima, Takuya Shirasaka, Yamato Kikkawa, Akihiro Taguchi, Kentaro Takayama, Takeshi Fukuhara, Tetsuro Watabe, Yuji Ito, Yoshio Hayashi. Novel Hybrid Compound of a Plinabulin Prodrug with an lgG Binding Peptide for Generating a Tumor Selective Noncovalent-Type Antibody-Drug Conjugate. Bioconjug. Chem .. 2016.07; 27(7); 1606-1613
Fusa Ogata, Katsuhito Fujiu, Sahohime Matsumoto, Yukiteru Nakayama, Munehiko Shibata, Yuichi Oike, lsao Koshima, Tetsuro Watabe, Ryozo Nagai, lchiro Manabe. Excess Lymphangiogenesis Cooperatively Induced by Macrophages and CD4(+) T Cells Drives the Pathogenesis of Lymphedema.J. Invest. Dermatol.. 2016.03; 136(3); 706-714
Akihiro Katsura, Hiroshi I Suzuki, Toshihide Ueno, Hajime Mihira, Tomoko Yamazaki, Takahiko Yasuda, Tetsuro Watabe, Hiroyuki Mano, Yoshitsugu Yamada, Kohei Miyazono. MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β. Genes Cells. 2016.01; 21 (1); 99-116
Masato Morikawa, Daizo Koinuma, Anna Mizutani, Natsumi Kawasaki, Katarina Holmborn,Anders Sundqvist, Shuichi Tsutsumi, Tetsuro Watabe, Hiroyuki Aburatani, Carl-Henrik Heldin, Kohei Miyazono. BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different KrOppel-like Factors. Stem Cell Reports. 2016.01; 6(1); 64-73
口腔放射線腫瘍学（三浦）
Atsushi Kaida, Hiroshi Watanabe, Kazuma Toda, Keiko Yuasa-Nakagawa, Ryoichi Yoshimura, Masahiko Miura. Effects of dose rate on early and late complications in low dose rate brachytherapy for mobile tongue carcinoma using lr-192 sources. Oral Radiol. 2016.12; published online;
Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. Kinetic analysis of radiation-induced cell-cycle alterations in Hela cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci). Radiat Environ Med. 2016.08; 5(2); 16-21
Taito Asahina, Atsushi Kaida, Tatsuaki Goto, Ryo—lchi Yoshimura, Keisuke Sasai, Masahiko Miura. Temporo-spatial cell-cycle kinetics in Helo cells irradiated by lr-192 high dose-rate remote afterloading system (HDR-RALS). Radiat Oncol. 2016.07; 11; 99
Wu T, Wang S, Wu J, Lin Z, Sui X, Xu X, Shimizu N, Chen B, Wang X .. lcaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma. J Exp Clin Cancer Res .. 34; 17
Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Shimizu N, Reghunathan R, Chuc】 HC, Yeoh AE, Quah TC, Koh LP, Tan PL Chng WJ .. Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotype. Leuk Lymphoma .. 56; 2408-2415
Shotaro Ando, Jun-lchi Kawada, Takahiro Watanabe, Michio Suzuki, Yoshitaka Sato, Yuka Torii, Masato Asai, Fumi Goshima, Takayuki Murata, Norio Shimizu, Yoshinori Ito, Hiroshi Kimura. Tofacitinib induces G 1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Oncotarget. 2016.11; 7(47); 76793-76805
Natsuko lnazawa, Tsukasa Hori, Masanori Nojima, Makoto Saito, Keita lgarashi, Masaki Yamamoto, Norio Shimizu, Yoko Yuto, Hiroyuki Tsutsumi. Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay. J. Med. Virol .. 2016.07;
Natsuko lnazawa, Tsukasa Hori, Masaki Yamamoto, Naoki Hatakeyama, Yuko Yoto, Masanori Nojima, Hiroshi Yasui, Nobuhiro Suzuki, Norio Shimizu, Hiroyuki Tsutsumi. HHV-6 encephalitis may complicate the early phase after allogeneic hematopoietic stem cell transplantation: Detection by qualitative multiplex PCR and subsequent quantitative real-time PCR. J. Med. Virol .. 2016.02; 88(2); 319-323
Watanabe Y, Honda S, Konishi A, Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S .. Autophagy controls centrosome number by degrading Cep63. Nature Commun .. 2016; 7; 13508
Torii S, Yoshida T, Arakawa S, Honda S, Nakanishi A, Shimizu S .. Identification of PPM 1 D as an essential Ulkl phosphatase for genotoxic stress-induced autophagy. EMBO R .. 2016; 17(11); 1552-1564
Konishi A, Izumi T, Shimizu S .. TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends. J.Biol.Chem .. 2016; 291 (39); 20798-20810
Yamaguchi H, Arakawa S, Kanaseki T, Miyatsuka T, Fujitani Y, Watada H, Tsujimoto Y, Shimizu S .. Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J .. 2016; 35 (18); 1991- 2007
Nasu Y, Benke A, Arakawa S, Yoshida GJ, Kawamura G, Manley S, Shimizu S, Ozawa T. In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Scientific Reports .. 2016; 13(6); 27505
T.yoshida,M.Tsujioka,S.honda,M.Tanaka,S.Shimizu .. Autophagy suppresses cell migration by degrading GEF-Hl, a RhoA GEF. OncoTaget .. 2016; 7(23); 34420-34429
H.uchiyama,K.Uehara, T.Nagashima,A.Nakata,K.Sato,Y.Mihara, K.Komatsu,J.Takanari,S.Shimizu,
K.Wakame. Global Liver Gene Expression Analysisi on a Murine Metabolic Syndrome Model Treated by Low-molecularweight Lychee Fruit Polyphenol. Anticancer Research .. 2016; 36(7); 3705-3713
Arai A, Sakashita C, Hirose C, lmadome K, Yamamoto M, Jinta M, Fujiwara S, Tomita M, Shimizu N, Morio T, and Miura 0 .. Hematopoietic stem cell transplantation for adults with EBY-positive Tor NK-cell lymphoproliferative disorders: efficacy and predictive markers Bone Marrow Transplantation. 2016;
遺伝子発現制御学（黒柳）
Tomioka M, Naito Y, Kuroyanagi H, lino Y. Splicing factors control C.elegans behavioural learning in a single neuron by producing DAF-2c receptor. Nat Commun. 7: 11645, 2016.
Takei S, Togo-Ohno M, Suzuki Y, Kuroyanagi H. Evolutionarily conserved autoregulation of alternative pre-mRNA splicing by ribosomal protein L 1 Oa. Nucleic Acids Research. 44: 5585-5596, 2016.
低酸素生物学（中山）
Katsuta E Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A Matsumura S, Mitsunori Y, Ban D,Ochiai T, Kudo A Fukamachi H, Tanaka H, NQkQYQmQ K., Arii S, Tanabe M. CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. Int. J. Oncol. 48, 657-669, (2016).
Kikuchi D., Tanimoto K., and NQkQyQmQ K.* CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IREl a and PERK. Biochem. Biophys. Res. Commun. 469, 243-250, (2016).
総説
分子腫瘍医学（田中）
Tanaka S. Molecular analysis for therapeutic targets of pancreatic cancer. in Molecular diagnosis and targeting for thoracic and gastrointestinal malignancy, eds. Shimada Y, Yanaga K.(Springer), in press.
Tanaka S .. Molecular pathogenesis and targeted therapy of pancreatic cancer. Annals Surgical Oncology. 2016.02; Suppl (2); 197-205
分子細胞機能学（中濱）
Yasuhiro Yoshimatsu, Hideki Miyazaki, Tetsuro Watabe. Roles of signaling and transcriptional networks in pathological lymphangiogenesis. Adv. Drug Deliv. Rev .. 2016.04; 99(Pt B); 161-171
Yumiko Oishi, lchiro Manabe. Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue. Clin. Exp. Pharmacol. Physiol.. 2016.03; 43(3); 294-303
Yumiko Oishi, lchiro Manabe. Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue. Clin. Exp. Pharmacol. Physiol.. 2016.03; 43(3); 294-303
Sumio Hayakawa, Kieko Saito、Noriyuki Miyoshi, Tomokazu Ohishi, Yumiko Oishi, Mamoru Miyoshi, Yoriyuki Nakamura. Anti-Cancer Effects of Green Tea by Either Anti- or Pro- Oxidative Mechanisms. Asian Pac. J. Cancer Prev .. 2016; 17(4); 1649-1654
病態細胞生物学（清水）
清水重臣オートファジーと細胞死実験医学増刊号「細胞死研究の基礎と臨床（仮）」．
Satoko Arakawa,Shinya Honda,Satoru Torii,Masatsune Tsujioka,Shigeomi Shimizu .. Monitoring of Atg5- independent Mitophagy. Methods in Molecular Biology,"Mitophagy".
