13:40-14:00

Opening Remarks

13:40-13:50

Kohei Miyazono (The University of Tokyo, Japan)

13:50-14:00

Fumimaro Takaku (Intractable Diseases (Nanbyo) Research Foundation, Japan)

14:00-15:45

Session 1 “New Era of BMP Research-1”

Chair:

Vicki Rosen (Harvard School of Dental Medicine, USA)
Takeshi Imamura (Ehime University, Japan)

14:00-14:30

Vicki Rosen (Harvard School of Dental Medicine, USA)

BMP pathway and its inhibitors in the skeleton

14:30-14:45

Yoav I. Henis (Tel Aviv University, Israel)

The Cholesterol Connection: Membrane Cholesterol Affects TGF-β Signaling by Transcriptional and Translational Regulation of TGF-β Downstream Signaling Components

14:45-15:00

Yang Chai (University of Southern California, USA)

Alk5-Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development

15:00-15:15

Jian Xu (University of Southern California, USA)

Methylation activates Smad6 to define BMP signaling

15:15-15:30

Hilary Ashe (University of Manchester, UK)

Dynamic BMP signal reception on a cellular projection in the Drosophila ovarian germline

15:30-15:45

Takeshi Imamura (Ehime University, Japan)

Development of optical imaging techniques in BMP signaling and cancer research

15:45-16:00

Break

16:00-17:45

Session 2 “New Era of BMP Research -2”

Chair:

Paul Yu (Brigham and Women's Hospital, USA)
Masato Morikawa (The University of Tokyo, Japan)

16:00-16:30

Paul Yu (Brigham and Women's Hospital, USA)

ACTRIIA-Fc rebalances activin/GDF vs. BMP signaling to attenuate experimental pulmonary hypertension

16:30-16:45

Masato Morikawa (The University of Tokyo, Japan)

The ALK-1/SMAD/ATOH8 axis protects against hypoxia and development of pulmonary arterial hypertension

16:45-17:00

Osamu Nakagawa (National Cerebral and Cardiovascular Center Research Institute, Japan)

Transcriptional regulation and physiological significance of BMP-ALK1 signal target genes in embryonic vascular endothelial cells

17:00-17:15

Jean-Jacques Feige (INSERM, France)

Genetic deletion of BMP9 causes liver sinusoidal endothelial cell capillarization and liver fibrosis in 129/Ola mice

17:15-17:30

Fumiko Itoh (Tokyo University of Pharmacy and Life Sciences, Japan)

Endothelial TGF-β/BMP signaling is essential for maintaining vascular function

17:30-17:45

Andreas Benn (Katholieke Universiteit Leuven, Belgium)

Crossing borders: BMP-SMAD-dependent regulation of endothelial barrier integrity and vascular permeability

17:45-18:00

Break

18:00-19:00

“Marshall R Urist Lecture”

Chair:

Kohei Miyazono (The University of Tokyo, Japan)

Speaker:

Carl-Henrik Heldin (Uppsala University, Sweden)

Signaling via TGF-β receptors – a possible target in tumor therapy

DAY 2 October 25th (Thu)

9:00-10:45

Session 3 “Development”

Chair:

Mary Mullins (University of Pennsylvania, USA)
Osamu Shimmi (University of Helsinki, Finland)

09:00-09:30

Mary Mullins (University of Pennsylvania, USA)

Shaping and interpretation of a BMP morphogen signaling gradient in tissue patterning

09:30-10:00

An Zwijsen (Katholieke Universiteit Leuven, Belgium)

Heterogenous BMP-SMAD signalling in the lymphatic vasculature of mice

10:00-10:30

Osamu Shimmi (University of Helsinki, Finland)

Dynamic 3D structure directs BMP morphogen signaling during Drosophila wing morphogenesis

10:30-10:45

Tadayoshi Hayata (Tokyo University of Science, Japan)

The ovarian hemorrhages caused by the phosphatase Dullard deficiency is rescued by administration of a BMP type I receptor kinase inhibitor

10:45-11:00

Break

11:00-12:45

Session 4 “Antagonists / Intracellular Signaling 1”

Chair:

Aristidis Moustakas (Uppsala University, Sweden)
Keiji Miyazawa (University of Yamanashi)

11:00-11:30

Derek Brazil (Queen's University Belfast, UK)

New insights into Gremlin1 signalling in development and disease

11:30-12:00

Aristidis Moustakas (Uppsala University, Sweden)

Antagonism or synergy between BMP and TGF-β pathways in cancer?

12:00-12:15

Arunima Murgai (Freie Universität Berlin, Germany)

Noggin Regulates Myogenesis and Maintains the Myogenic Cell Fate

12:15-12:30

Jason C. McCoy (University of Cincinnati, USA)

Novel structure of the myostatin antagonist WFIKKN2 follistatin domain

12:30-12:45

Andrew P. Hinck (University of Pittsburgh School of Medicine, USA)

Structure-function studies of the TGF-β family co-recptor betaglycan

13:00-14:00

Luncheon Seminar

Chair:

Naoyuki Takahashi (Matsumoto Dental University, Japan)

Speaker:

Takenobu Katagiri (Saitama Medical University, Japan)

Gifts from C2C12 myoblasts

14:00-15:00

Poster Session 1

15:00-16:45

Session 5 “Intracellular Signaling 2”

Chair:

Petra Knaus (Freie Universität Berlin, Germany)
Mitsuyasu Kato ((University of Tsukuba, Japan)

15:00-15:30

Akiko Hata (University of California, San Francisco, USA)

Mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia

15:30-16:00

Rik Derynck (University of California, San Francisco, USA)

Roles of TGF-β signaling in stabilization of epithelial-mesenchymal transition,cellular response to insulin and TGF-β signal amplification

16:00-16:30

Petra Knaus (Freie Universität Berlin, Germany)

Imbalance in endothelial BMP/TGFβ signaling is promoted through an extracellular mechanotransduction circuit

16:30-16:45

Erich J. Goebel (University of Cincinnati, USA)

Characterization of Receptor Specificity within the Activin Subclass member, GDF11

16:45-17:00

Break

17:00-18:45

Session 6 “Intracellular Signaling 3”

Chair:

Peter ten Dijke (Leiden University, The Netherlands)
Hideaki Ijichi (The University of Tokyo, Japan)

17:00-17:30

Caroline S. Hill (The Francis Crick Institute, UK)

A new mechanism of receptor activation to induce SMAD1/5 signalling

17:30-18:00

Ye-Guang Chen (Tsinghua University, China)

Regulation of Intestinal Epithelium Homeostasis by BMP

18:00-18:30

Peter ten Dijke (Leiden University, The Netherlands)

Promoting BMP signaling to inhibit breast cancer invasion and metastasis

18:30-18:45

Hideaki Ijichi (The University of Tokyo, Japan)

Crucial Roles of BMP signaling in pancreatic ductal adenocarcinoma initiation and progression in a genetically-engineered mouse model

DAY 3 October 26th (Fri)

9:00-10:45

Session 7 “Bone”

Chair:

Slobodan Vukicevic (University of Zagreb, Croatia)
Shingo Maeda (Kagoshima University, Japan)

09:00-09:30

Yuji Mishina (University of Michigan, USA)

Molecular and cellular analyses of BMP-dependent coupling signals between osteoclasts and osteoblasts during bone remodeling

09:30-09:45

Kuber Sampath (Sanofi-Genzyme Research Center, USA)

Role of BMPs in Orthopedic Medicine: Progress and Challenges

09:45-10:15

Slobodan Vukicevic (University of Zagreb, Croatia)

Autologous Bone Graft Substitute (ABGS): Composed of Recombinant HumanBMP6 (rhBMP6) Delivered within Autologous Blood Coagulum (ABC): Preclinical and Clinical Studies

10:15-10:30

Shingo Maeda (Kagoshima University, Japan)

Atoh8 is induced by BMP signaling to increases bone volume in adult mice

10:30-10:45

Junichi Kushioka (Osaka University, Japan)

SMURF2 E3 ubiquitin ligase is engaged on BMP/SMAD signaling pathway.

10:45-11:00

Break

11:00-12:45

Session 8 “Cancer”

Chair:

Chris Jones (The Institute of Cancer Research, London, UK)
Daizo Koinuma (The University of Tokyo, Japan)

11:00-11:30

Seong-jin Kim (Seoul National University, Korea)

Potential cancer therapeutics targeting TGF-β signalling

11:30-12:00

Chris Jones (The Institute of Cancer Research, London, UK)

Preclinical efficacy of combined ACVR1 and PI3K/mTOR inhibition in DIPG

12:00-12:30

Kohei Miyazono (The University of Tokyo, Japan)

Mechanisms of action of BMPs in human malignant glioma

12:30-12:45

Jerome Fortin (Campbell Family Cancer Research Institute, Canada)

Uncovering How ACVR1 Mutations Drive Diffuse Intrinsic Pontine Glioma

13:00-15:00

Lunch and Free Poster Discussion

14:30-15:30

Special Lecture at Tokyo Medical and Dental University

Chair:

Kohei Miyazono (The University of Tokyo, Japan)

Speaker:

Hari Reddi (University of California, Davis, USA)

Regeneration of bone and articular cartilage: Role of bone morphogenetic proteins

DAY 4 October 27th (Sat)

9:00-10:45

Session 9 “Vascular & Lymphovascular”

Chair:

Kristian Pietras (Lund University, Sweden)
Tetsuro Watabe (Tokyo Medical and Dental University, Japan)

09:00-09:30

Sabine Bailly (Institute of Grenoble, France)

Respective roles of BMP9 and BMP10 in vascular remodelling

09:30-10:00

Tetsuro Watabe (Tokyo Medical and Dental University, Japan)

BMP family signals in the formation and maintenance of vascular systems

10:00-10:30

Kristian Pietras (Lund University, Sweden)

Contrasting effects of BMP signaling in the pro-metastatic tumor microenvironment

10:30-10:45

Catalina Gomez-Puerto (Leiden University Medical Center, The Netherlands)

The importance of autophagy in BMPRII degradation and its role in pulmonary arterial hypertension

10:45-11:00

Break

11:00-12:45

Session 10 “HHT/PAH”

Chair:

Nicholas W. Morrell (University of Cambridge, UK)
Fumiko Itoh (Tokyo University of Pharmacy and Life Sciences, Japan)

11:00-11:30

Helen Arthur (Newcastle University, UK)

Loss of Endothelial Endoglin leads to high output heart failure through aberrant VEGF signalling

11:30-12:00

Nicholas W. Morrell (University of Cambridge, UK)

The role of BMP9 in pulmonary vascular disease

12:00-12:30

Masaharu Kataoka (Keio University, Japan)

BMPR2 Mutations in Pulmonary Arterial Hypertension in a Large Homogeneous Japanese Population

12:30-12:45

Marie-Jose Goumans (Leiden University Medical Center, The Netherlands)

BMP9 phenotypically alters the pulmonary microvascular endothelium in Pulmonary Arterial Hypertension

13:00-15:00

Lunch and Poster Session-2

15:00-16:45

Session 11 “Clinics/ New Technology”

Chair:

Ravi Kumar (Acceleron Pharma Inc., USA)
Susumu Itoh (Showa Pharmaceutical University, Japan)

15:00-15:30

Ravi Kumar (Acceleron Pharma Inc., USA)

Use of Novel Selective Ligand Traps in Various Disease Models

15:30-15:45

Susumu Itoh (Showa Pharmaceutical University, Japan)

Chondrocyte differentiation by coordination between BMP (Bone Morphogenetic Protein)-mediated Smad and non-Smad pathways

15:45-16:00

William D Carlson (Massachusetts General Hospital/Harvard Medical School, USA)

Clinical development of BMP mimetics

16:00-16:15

Daniel Graf (University of Alberta, Canada)

Critical involvement of BMP2 in bone catabolic processes during periodontal Disease

16:15-16:30

Susanne Hildebrandt (Freie Universität Berlin, Germany)

Role of the ACVR1/ALK2 receptor in endothelial cells derived from iPSCs of FOP patients

16:30-16:45

Satoshi Miyamoto (Tokyo Medical and Dental University, Japan)

Anti-tumor effect of BMP4 on human neuroblastoma cell lines

16:45-17:00

Break

17:00-18:00

Charles Huggins Lecture

Chair:

Hari Reddi (University of California, Davis, USA)

Speaker:

Takenobu Katagiri (Saitama Medical University, Japan)

Bone morphogenetic proteins: critical regulators of bone formation

DAY 5 October 28th (Sun)

9:00-10:45

Session 12 “FOP-1”

Chair:

Alex Bullock (University of Oxford, UK)
Takenobu Katagiri (Saitama Medical University, Japan)

09:00-09:30

Frederick S. Kaplan (University of Pennsylvania, USA)

Hope for escape from a prison of bone

09:30-10:00

Eileen M. Shore (University of Pennsylvania, USA)

ACVR1 R206H – Heterotopic Ossification and Skeletal Bone

10:00-10:30

Alex Bullock (University of Oxford, UK)

Molecular basis of ALK2 activation and small molecule inhibition in FOP

10:30-10:45

Pamela C. Yelick (Tufts University, USA)

Adult zebrafish models for Fibrodysplasia Ossificans Progressiva

10:45-11:00

Break

11:00-12:45

Session 13 “FOP-2”

Chair:

Aris N. Economides (Regeneron Pharmaceuticals Inc., USA)
Nobuhiko Haga (The University of Tokyo, Japan)

11:00-11:30

Aris N. Economides (Regeneron Pharmaceuticals Inc., USA)

Insights into the mechanism of signaling by ACVR1 in Fibrodysplasia Ossificans Progressiva

11:30-12:00

Junya Toguchida (Kyoto University, Japan)

Disease-specific iPS cells disclose the novel pathomechanism and provide a plattform for clinical trial for patients with FOP

12:00-12:30

Nobuhiko Haga (The University of Tokyo, Japan)

Activities of the research group on fibrodysplasia ossificans progressiva in Japan

12:30-12:45

Gonzalo Sanchez Duffhues (Leiden University Medical Center, The Netherlands)

Identification of Novel Macrocyclic ALK2 Inhibitors for Fibrodysplasia Ossificans Progressiva Using Patient-Derived Endothelial Colony Forming Cells

12:45-13:00

Closing Remarks

Kohei Miyazono (The University of Tokyo, Japan)